Nielsen H E
Department of Paediatrics, Copenhagen University Hospital, Hvidovre, Denmark.
Acta Paediatr Scand. 1988 Jan;77(1):125-31. doi: 10.1111/j.1651-2227.1988.tb10610.x.
The purpose of this study was to determine if Schönlein-Henoch purpura represents an abnormal host response to microorganisms. Among 1,222 cases, representing all new Danish cases in children during the years 1977-84, there was no tendency for the cases to cluster; this means that the disease is not caused by a single, contagious agent. In a smaller sample of 281 children examined in detail, a higher number than expected attended day nursery or nursery school and 17% had received antibiotic treatment during the week prior to admission. The latter findings, together with the seasonal variation of the incidence and the activation of the immune apparatus in many cases, suggest that Schönlein-Henoch purpura may be triggered by infection with several different microorganisms, but there is no evidence that a single one such as the streptococcus is the major offender.
本研究的目的是确定过敏性紫癜是否代表宿主对微生物的异常反应。在1977年至1984年期间丹麦所有新发病的儿童病例中，选取了1222例进行研究，这些病例没有聚集倾向；这意味着该疾病不是由单一的传染性病原体引起的。在一个由281名儿童组成的较小样本中，经详细检查发现，上过日托所或幼儿园的儿童数量高于预期，并且17%的儿童在入院前一周接受过抗生素治疗。后一项发现，连同发病率的季节性变化以及许多病例中免疫器官的激活情况，表明过敏性紫癜可能由几种不同的微生物感染引发，但没有证据表明单一的某种微生物（如链球菌）是主要病因。
