Keller M A, Gendreau-Reid L, Heiner D C, Rodriguez A, Short J A
Department of Pediatrics, UCLA School of Medicine, Torrance.
Acta Paediatr Scand. 1988 Jan;77(1):24-9. doi: 10.1111/j.1651-2227.1988.tb10592.x.
Colostrum, mature milk, and paired plasma samples were obtained from 10 postpartum women who had not been previously studied. The geometric mean concentration of IgG4 in colostrum (3.3 micrograms/ml) was similar to the mean concentration in mature milk (3.0 micrograms/ml). The arithmetic mean for the percent of IgG = IgG4 was 10.3 +/- 3.3% for colostrum, 10.3 +/- 3.1% for mature milk, 2.6 +/- 0.3% for early plasma, and 1.7 +/- 0.3% for later plasma. Local mammary production of immunoglobulin was determined by subtracting the estimated serum contribution from the measured concentration in colostrum or milk. Evidence for local mammary production of IgG4 was found in 5 of 10 colostrum samples and 8 of 10 mature milk samples. These observations indicate that the previously observed selective enrichment of IgG4 in colostrum is also true for mature milk. These are the first studies suggesting continued local production of any immunoglobulin other than IgA in mature human breast milk.
从10名此前未接受过研究的产后女性身上采集了初乳、成熟乳及配对的血浆样本。初乳中IgG4的几何平均浓度（3.3微克/毫升）与成熟乳中的平均浓度（3.0微克/毫升）相似。初乳中IgG = IgG4的算术平均值为10.3±3.3%，成熟乳为10.3±3.1%，早期血浆为2.6±0.3%，晚期血浆为1.7±0.3%。通过从初乳或乳汁的测量浓度中减去估计的血清贡献来确定乳腺局部免疫球蛋白的产生。在10份初乳样本中有5份、10份成熟乳样本中有8份发现了乳腺局部产生IgG4的证据。这些观察结果表明，此前观察到的初乳中IgG4的选择性富集在成熟乳中同样存在。这些是首次表明成熟人母乳中除IgA外还有其他免疫球蛋白持续局部产生的研究。
