Ma Zhonghui, Yan Su, Dong Haoxin, Wang Huifen, Luo Yonggang, Wang Xi
Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Precision Medicine Center, Gene Hospital of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Med (Lausanne). 2021 Feb 22;8:644130. doi: 10.3389/fmed.2021.644130. eCollection 2021.
Brain abscesses are associated with an increased long-term risk of new seizures and increased mortality within several years after infection. Common microorganisms that cause brain abscesses include bacteria, fungi, and mycoplasma. We report a 75-year-old man with a brain abscess caused by , an oral pathogen. Based on the clinical condition, we suspected that the patient had a blood-borne brain abscess, and he received antibiotics and systemic supportive treatment. The patient developed shock for the second time after negative Gram-staining results. Metagenomics next-generation sequencing showed one strain from the oral microbiome, confirming our hypothesis, and targeted antibiotic treatment was administered quickly. Thus, we report a case in which genomic analysis was the critical factor in determining the best antimicrobial therapy for administration.
脑脓肿与新发癫痫的长期风险增加以及感染后数年内死亡率升高有关。引起脑脓肿的常见微生物包括细菌、真菌和支原体。我们报告了一名75岁男性，其脑脓肿由一种口腔病原体引起。根据临床情况，我们怀疑该患者患有血源性脑脓肿，他接受了抗生素和全身支持治疗。革兰氏染色结果为阴性后，患者第二次发生休克。宏基因组学下一代测序显示来自口腔微生物群的一个菌株，证实了我们的假设，并迅速给予了针对性抗生素治疗。因此，我们报告了一例基因组分析是确定最佳抗菌治疗方案的关键因素的病例。
