The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, United States of America.
Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, United States of America.
PLoS Biol. 2023 Aug 1;21(8):e3002225. doi: 10.1371/journal.pbio.3002225. eCollection 2023 Aug.
Pathogen genome sequencing has become a routine part of our response to active outbreaks of infectious disease and should be an important part of our preparations for future epidemics. In this Essay, we discuss the innovations that have enabled routine pathogen genome sequencing, as well as how genome sequences can be used to understand and control the spread of infectious disease. We also explore the impact of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic on the field of pathogen genomics and outline the challenges we must address to further improve the utility of pathogen genome sequencing in the future.
病原体基因组测序已成为我们应对传染病爆发的常规手段,也应该成为我们为未来的疫情做准备的重要一环。在这篇文章中,我们讨论了使病原体基因组常规测序成为可能的创新,以及基因组序列如何用于了解和控制传染病的传播。我们还探讨了严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)大流行对病原体基因组学领域的影响,并概述了我们必须解决的挑战,以进一步提高病原体基因组测序在未来的实用性。