Reproductive Physiology and Endocrinology Laboratory, Department of Human Physiology, Tripura University (A Central University), Agartala, India.
J Food Biochem. 2021 Apr;45(4):e13697. doi: 10.1111/jfbc.13697. Epub 2021 Mar 10.
The global prevalence of metabolic disorders including hypertension, dyslipidemia, insulin resistance, nonalcoholic fatty liver, and cardiovascular diseases seemed to affect people of all ages cutting across the national, economic, and demographic barrier. Therefore, the prevention of metabolic disorders is considered of paramount importance. The dietary role of nutrients including vitamins and minerals is one of the recommended preventive measures against metabolic disorders in modern society. Recently, dietary calcium, a common nutrient not only showed a beneficial effect against obesity through weight management, but also gained great attention against the risk of metabolic disorders. Though dietary calcium shows several beneficial effects against metabolic disorders but some inconsistent results were also reported. So, the present review aims to extract recent knowledge as well as their possible underlying mechanisms regarding the role of dietary calcium against metabolic disorders. The present review also discusses the negative impact as well as prospect of calcium intake on health issues. In summary, high calcium diet prevents the harmful consequences of metabolic disorders by regulating hormonal actions, alteration in intracellular calcium level, renin-angiotensin system, intestinal fat absorption, fecal fat excretion, lipid metabolism, carbohydrate metabolism, inflammation, and oxidative stress which together improve the metabolic health of an individual. PRACTICAL APPLICATIONS: Metabolic disorder is a global health issue across all sections of society and is growing rapidly in spite of several attempts by the scientific community to prevent it. Recently dietary calcium gained great attention in the last few years for its role in the management and treatment of metabolic disorders. The current review highlights the beneficial role of dietary calcium against several metabolic complications by exploring their underlying mechanisms at cellular level. This study will provide valuable information regarding the recommendation of dietary calcium in health policy as well as its inclusion in the dietary chart through calcium-rich foods and/or taking calcium supplements which can be a useful approach in preventing the risk of metabolic disorder depending on the health status of an individual.
全球范围内代谢紊乱的流行率，包括高血压、血脂异常、胰岛素抵抗、非酒精性脂肪肝和心血管疾病，似乎影响了各个年龄段的人群，跨越了国家、经济和人口统计学的障碍。因此，预防代谢紊乱被认为至关重要。营养素，包括维生素和矿物质，在现代社会中的饮食作用是预防代谢紊乱的推荐措施之一。最近，膳食钙作为一种常见的营养素，不仅通过体重管理对肥胖有有益的作用，而且对代谢紊乱的风险也引起了极大的关注。虽然膳食钙对代谢紊乱有几种有益的作用，但也有一些不一致的结果。因此，本综述旨在提取有关膳食钙对代谢紊乱作用的最新知识及其可能的潜在机制。本综述还讨论了钙摄入对健康问题的负面影响和前景。总之，高钙饮食通过调节激素作用、细胞内钙水平的改变、肾素-血管紧张素系统、肠道脂肪吸收、粪便脂肪排泄、脂质代谢、碳水化合物代谢、炎症和氧化应激来防止代谢紊乱的有害后果，从而改善个体的代谢健康。实际应用：代谢紊乱是一个全球性的健康问题，跨越了社会的各个阶层，尽管科学界做了几次尝试来预防，但它的发病率仍在迅速上升。最近，膳食钙在过去几年中因其在代谢紊乱的管理和治疗中的作用而受到了极大的关注。本综述通过探索其在细胞水平上的潜在机制，强调了膳食钙对几种代谢并发症的有益作用。这项研究将提供有关在健康政策中推荐膳食钙的宝贵信息，以及通过富含钙的食物或服用钙补充剂将其纳入饮食图表的信息，这可以根据个体的健康状况成为预防代谢紊乱风险的有用方法。
