State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Medical College, Soochow University, Suzhou, China.
Brain Behav. 2021 May;11(5):e02099. doi: 10.1002/brb3.2099. Epub 2021 Mar 10.
In adolescence, the brain is still maturing, and disorders in maturation may affect the normal development of the brain. Exposure to titanium dioxide nanoparticles (TiO NPs) has various potential negative effects on the central nervous system. Bergamot essential oil (BEO) has been found to be effective for neuroprotection.
The rats were injected intraperitoneally with TiO NPs (20 mg/kg) and/or BEO (200 mg/kg). The endogenous antioxidant state and inflammatory parameters were estimated using ELISA kits, and then the memory ability and anxiety-like behavior in rats were assessed.
TiO NPs exposure during the adolescent period induced anxiety-like behavior, cognitive impairment, neuroinflammation and oxidative damage in hippocampus, and BEO treatment could significantly ameliorate the neurotoxicities induced by TiO NPs exposure.
Our results suggest that the negative effects of TiO NPs exposure during the adolescent period on anxiety-like behavior and cognitive function may be related to oxidative stress and neuroinflammation induced by TiO NPs exposure. In addition, BEO may ameliorate the neurotoxicities induced by TiO2 NPs exposure in adolescent rats through the antioxidant and anti-inflammatory activity of BEO.
在青少年时期，大脑仍在发育，发育障碍可能会影响大脑的正常发育。二氧化钛纳米粒子 (TiO NPs) 的暴露对中枢神经系统有各种潜在的负面影响。已发现佛手柑精油 (BEO) 对神经保护有效。
将大鼠腹膜内注射 TiO NPs（20 mg/kg）和/或 BEO（200 mg/kg）。使用 ELISA 试剂盒评估内源性抗氧化状态和炎症参数，然后评估大鼠的记忆能力和焦虑样行为。
青春期暴露于 TiO NPs 会引起焦虑样行为、认知障碍、海马体中的神经炎症和氧化损伤，而 BEO 处理可显著改善 TiO NPs 暴露引起的神经毒性。
我们的结果表明，青春期 TiO NPs 暴露对焦虑样行为和认知功能的负面影响可能与 TiO NPs 暴露引起的氧化应激和神经炎症有关。此外，BEO 可能通过 BEO 的抗氧化和抗炎活性来改善青春期大鼠中 TiO2 NPs 暴露引起的神经毒性。
