Avola Rosanna, Furnari Alessandro Giuseppe, Graziano Adriana Carol Eleonora, Russo Alessandra, Cardile Venera
Faculty of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.
Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.
Antioxidants (Basel). 2024 Jan 31;13(2):178. doi: 10.3390/antiox13020178.
Neuroinflammation, a pivotal factor in the pathogenesis of various brain disorders, including neurodegenerative diseases, has become a focal point for therapeutic exploration. This review highlights neuroinflammatory mechanisms that hallmark neurodegenerative diseases and the potential benefits of essential oils in counteracting neuroinflammation and oxidative stress, thereby offering a novel strategy for managing and mitigating the impact of various brain disorders. Essential oils, derived from aromatic plants, have emerged as versatile compounds with a myriad of health benefits. Essential oils exhibit robust antioxidant activity, serving as scavengers of free radicals and contributing to cellular defense against oxidative stress. Furthermore, essential oils showcase anti-inflammatory properties, modulating immune responses and mitigating inflammatory processes implicated in various chronic diseases. The intricate mechanisms by which essential oils and phytomolecules exert their anti-inflammatory and antioxidant effects were explored, shedding light on their multifaceted properties. Notably, we discussed their ability to modulate diverse pathways crucial in maintaining oxidative homeostasis and suppressing inflammatory responses, and their capacity to rescue cognitive deficits observed in preclinical models of neurotoxicity and neurodegenerative diseases.
神经炎症是包括神经退行性疾病在内的各种脑部疾病发病机制中的关键因素，已成为治疗探索的焦点。本综述重点介绍了作为神经退行性疾病标志的神经炎症机制，以及精油在对抗神经炎症和氧化应激方面的潜在益处，从而为管理和减轻各种脑部疾病的影响提供了一种新策略。精油源自芳香植物，已成为具有多种健康益处的多功能化合物。精油具有强大的抗氧化活性，可作为自由基清除剂，有助于细胞抵御氧化应激。此外，精油还具有抗炎特性，可调节免疫反应并减轻各种慢性疾病中涉及的炎症过程。我们探讨了精油和植物分子发挥其抗炎和抗氧化作用的复杂机制，揭示了它们的多方面特性。值得注意的是，我们讨论了它们调节维持氧化稳态和抑制炎症反应所必需的各种途径的能力，以及它们挽救在神经毒性和神经退行性疾病临床前模型中观察到的认知缺陷的能力。
