Donahue R P, Abbott R D, Reed D M, Yano K
Department of Medicine, University of Massachusetts Medical Center, Worcester 01655.
Am J Public Health. 1988 Jun;78(6):683-5. doi: 10.2105/ajph.78.6.683.
The relationship of physical activity to the development of definite coronary heart disease was examined separately in middle-aged (45-64 years) and elderly men (65-69 years) participating in the Honolulu Heart Program. After 12 years of follow-up, results indicate that increased levels of physical activity reported at study entry were inversely related to the risk of definite coronary heart disease in both age groups. In particular, among those aged 45 to 64 years, the rate of definite coronary heart disease in men who led active life styles was 30 per cent lower than the rate experienced by those who were less active (relative risk, 0.69; 95% confidence interval, 0.53, 0.88). In those older than 64 years, the rate of definite coronary heart disease in active men was less than half the rate experienced by those who led more sedentary life styles (relative risk, 0.43; 95% CI, 0.19, 0.99). These results continued to hold up when controlling for several cardiovascular risk factors and potentially confounding variables, supporting earlier observations that physical activity is beneficial in middle-age, and further suggesting that benefits may extend to the elderly male population as well.
在参与檀香山心脏项目的中年男性（45 - 64岁）和老年男性（65 - 69岁）中，分别研究了体力活动与确诊冠心病发病之间的关系。经过12年的随访，结果表明，在研究开始时报告的体力活动水平增加与两个年龄组确诊冠心病的风险呈负相关。特别是，在45至64岁的人群中，积极生活方式的男性确诊冠心病的发病率比不那么活跃的男性低30%（相对风险，0.69；95%置信区间，0.53，0.88）。在64岁以上的人群中，积极活动的男性确诊冠心病的发病率不到久坐生活方式男性的一半（相对风险，0.43；95%置信区间，0.19，0.99）。在控制了几个心血管危险因素和潜在的混杂变量后，这些结果仍然成立，这支持了早期的观察结果，即体力活动在中年有益，并且进一步表明这种益处可能也适用于老年男性人群。
