可替宁从体液中的清除：对烟草烟雾暴露无创测量的意义。
Elimination of cotinine from body fluids: implications for noninvasive measurement of tobacco smoke exposure.
作者信息
Jarvis M J, Russell M A, Benowitz N L, Feyerabend C
机构信息
Addiction Research Unit, Institute of Psychiatry, London, United Kingdom.
出版信息
Am J Public Health. 1988 Jun;78(6):696-8. doi: 10.2105/ajph.78.6.696.
Abstract
Cotinine elimination from plasma, saliva, and urine was studied over 11 days in five subjects (three nonsmokers and two occasional smokers). Half-lives for cotinine averaged 16-19 hours in the different body fluids (range 10 to 27 hours between subjects). There was no tendency for the half-life in saliva to be longer than in plasma or urine. We conclude that choice of body fluid for cotinine assay in smoking studies should depend on practical rather than pharmacokinetic considerations.
摘要
在5名受试者（3名不吸烟者和2名偶尔吸烟者）中对可替宁在血浆、唾液和尿液中的消除情况进行了为期11天的研究。在不同体液中，可替宁的半衰期平均为16 - 19小时（受试者之间的范围为10至27小时）。唾液中的半衰期没有比血浆或尿液中更长的趋势。我们得出结论，在吸烟研究中选择用于可替宁检测的体液应取决于实际情况而非药代动力学因素。
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