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1
Elimination of cotinine from body fluids: implications for noninvasive measurement of tobacco smoke exposure.可替宁从体液中的清除：对烟草烟雾暴露无创测量的意义。
Am J Public Health. 1988 Jun;78(6):696-8. doi: 10.2105/ajph.78.6.696.
2
Cotinine in the serum, saliva, and urine of nonsmokers, passive smokers, and active smokers.非吸烟者、被动吸烟者和主动吸烟者血清、唾液及尿液中的可替宁
Am J Public Health. 1988 Jun;78(6):699-701. doi: 10.2105/ajph.78.6.699.
3
Determination of cotinine in biological fluids of non-smokers by packed column gas-liquid chromatography.用填充柱气液色谱法测定非吸烟者生物体液中的可替宁。
J Pharm Pharmacol. 1986 Dec;38(12):917-9. doi: 10.1111/j.2042-7158.1986.tb03383.x.
4
Elimination of cotinine from body fluids: disposition in smokers and nonsmokers.可替宁从体液中的消除：吸烟者和非吸烟者的处置情况
Am J Public Health. 1989 Aug;79(8):1046-8. doi: 10.2105/ajph.79.8.1046.
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Simulation and evaluation of nicotine intake during passive smoking: cotinine measurements in body fluids of nonsmokers given intravenous infusions of nicotine.被动吸烟期间尼古丁摄入量的模拟与评估：对接受尼古丁静脉输注的非吸烟者体液中可替宁水平的测定
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Simultaneous estimation of nicotine and cotinine levels in biological fluids using high-resolution capillary-column gas chromatography combined with solid phase extraction work-up.使用高分辨率毛细管柱气相色谱法结合固相萃取预处理同时测定生物体液中的尼古丁和可替宁水平。
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Titrating exposure to tobacco smoke using cotinine--a minefield of misunderstandings.使用可替宁滴定接触烟草烟雾的程度——误解的雷区。
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Serum and saliva concentrations of cotinine in smokers and passive smokers.吸烟者和被动吸烟者中可替宁的血清及唾液浓度。
J Clin Chem Clin Biochem. 1989 Apr;27(4):230-1.

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本文引用的文献

1
Rapid gas-liquid chromatographic determination of cotinine in biological fluids.生物流体中可替宁的快速气-液色谱测定法。
Analyst. 1980 Oct;105(1255):998-1001. doi: 10.1039/an9800500998.
2
Smoking-induced changes in nicotine disposition: application of a new HPLC assay for nicotine and its metabolites.吸烟引起的尼古丁代谢变化：一种用于尼古丁及其代谢物的新型高效液相色谱分析法的应用
Clin Pharmacol Ther. 1982 Dec;32(6):769-80. doi: 10.1038/clpt.1982.235.
3
Smokers of low-yield cigarettes do not consume less nicotine.低焦油香烟的吸烟者摄入的尼古丁并不少。
N Engl J Med. 1983 Jul 21;309(3):139-42. doi: 10.1056/NEJM198307213090303.
4
Long-term switching to low-tar low-nicotine cigarettes.长期改用低焦油低尼古丁香烟。
Br J Addict. 1982 Jun;77(2):145-58. doi: 10.1111/j.1360-0443.1982.tb01416.x.
5
Improved gas chromatographic method for the determination of nicotine and cotinine in biologic fluids.用于测定生物体液中尼古丁和可替宁的改进气相色谱法。
J Chromatogr. 1981 Jan 2;222(1):61-70. doi: 10.1016/s0378-4347(00)81033-6.
6
Carboxyhemoglobin, cotinine, and thiocyanate assay compared for distinguishing smokers from non-smokers.比较碳氧血红蛋白、可替宁和硫氰酸盐检测以区分吸烟者和非吸烟者。
Clin Chem. 1984 Aug;30(8):1377-80.
7
Cotinine disposition and effects.可替宁的处置与作用。
Clin Pharmacol Ther. 1983 Nov;34(5):604-11. doi: 10.1038/clpt.1983.222.
8
Validation of self-reported smoking behavior: biochemical analyses of cotinine and thiocyanate.自我报告吸烟行为的验证：可替宁和硫氰酸盐的生化分析
Am J Public Health. 1983 Oct;73(10):1204-7. doi: 10.2105/ajph.73.10.1204.
9
Biochemical markers of smoke absorption and self reported exposure to passive smoking.烟雾吸收的生化标志物及自我报告的被动吸烟暴露情况
J Epidemiol Community Health. 1984 Dec;38(4):335-9. doi: 10.1136/jech.38.4.335.
10
Urinary cotinine as marker of breathing other people's tobacco smoke.尿可替宁作为吸入他人烟草烟雾的标志物。
Lancet. 1984 Jan 28;1(8370):230-1. doi: 10.1016/s0140-6736(84)92156-1.

可替宁从体液中的清除：对烟草烟雾暴露无创测量的意义。

Elimination of cotinine from body fluids: implications for noninvasive measurement of tobacco smoke exposure.

作者信息

Jarvis M J, Russell M A, Benowitz N L, Feyerabend C

机构信息

Addiction Research Unit, Institute of Psychiatry, London, United Kingdom.

出版信息

Am J Public Health. 1988 Jun;78(6):696-8. doi: 10.2105/ajph.78.6.696.

DOI:10.2105/ajph.78.6.696
PMID:3369603
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1350287/
Abstract

Cotinine elimination from plasma, saliva, and urine was studied over 11 days in five subjects (three nonsmokers and two occasional smokers). Half-lives for cotinine averaged 16-19 hours in the different body fluids (range 10 to 27 hours between subjects). There was no tendency for the half-life in saliva to be longer than in plasma or urine. We conclude that choice of body fluid for cotinine assay in smoking studies should depend on practical rather than pharmacokinetic considerations.

摘要

在5名受试者（3名不吸烟者和2名偶尔吸烟者）中对可替宁在血浆、唾液和尿液中的消除情况进行了为期11天的研究。在不同体液中，可替宁的半衰期平均为16 - 19小时（受试者之间的范围为10至27小时）。唾液中的半衰期没有比血浆或尿液中更长的趋势。我们得出结论，在吸烟研究中选择用于可替宁检测的体液应取决于实际情况而非药代动力学因素。