Yumoto Y, Okuda T, Kato Y, Tashima M, Sawada H, Yamagishi M, Uchino H
1st Dept. of Internal Medicine, Faculty of Medicine, Kyoto University.
Gan To Kagaku Ryoho. 1988 May;15(5):1783-6.
A patient with cancer of unknown primary site suffering from diffuse bone marrow metastasis and DIC, was treated with FAM (5-fluorouracil, adriamycin and mitomycin C) combination chemotherapy. She was a 58-year-old housewife. Bone marrow biopsy revealed that her marrow tissue was completely replaced by cancer cells, and bone scintigraphy showed diffuse bone marrow metastasis in all the vertebrae, sternum, pelvic bones and skull. After 5 months administration of 3 courses of FAM therapy, the cancer cells were completely eradicated in the bone marrow upon biopsy taken at almost the same position as the previous one. The values of CEA, CA 19-9 and CA 125 were normalized, suggesting that this therapy was very effective.
一名原发部位不明的癌症患者，伴有弥漫性骨髓转移和弥散性血管内凝血（DIC），接受了FAM（5-氟尿嘧啶、阿霉素和丝裂霉素C）联合化疗。她是一名58岁的家庭主妇。骨髓活检显示其骨髓组织完全被癌细胞取代，骨闪烁显像显示所有椎体、胸骨、骨盆和颅骨均有弥漫性骨髓转移。在进行3个疗程的FAM治疗5个月后，在与之前几乎相同的位置进行活检，骨髓中的癌细胞已被完全清除。癌胚抗原（CEA）、糖类抗原19-9（CA 19-9）和糖类抗原125（CA 125）的值恢复正常，表明该治疗非常有效。
