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与人类免疫缺陷病毒感染相关的分枝杆菌性脑脊膜炎

Mycobacterial meningomyelitis associated with human immunodeficiency virus infection.

作者信息

Woolsey R M, Chambers T J, Chung H D, McGarry J D

机构信息

Department of Neurology, St Louis University, MO.

出版信息

Arch Neurol. 1988 Jun;45(6):691-3. doi: 10.1001/archneur.1988.00520300111030.

DOI:10.1001/archneur.1988.00520300111030
PMID:3369978
Abstract

A homosexual man, seropositive for human immunodeficiency virus, developed back and leg pain that evolved, over three weeks, into a T-10 anesthetic, areflexic paraplegia. Spinal fluid examination showed lymphocytosis, markedly elevated spinal fluid protein, and hypoglycorrhachia. A spinal cord biopsy specimen disclosed an intramedullary granuloma containing acid-fast bacilli. The patient was treated with antituberculous drugs and had no progression of neurologic deficit. He died, eight months after first becoming ill, of Klebsiella pyelonephritis and septicemia. Mycobacterial meningomyelitis is presently the only known acquired immunodeficiency syndrome-related myelopathy responsive to specific treatment.

摘要

一名感染人类免疫缺陷病毒呈血清阳性的同性恋男子出现背部和腿部疼痛,在三周内发展为T-10节段感觉缺失、无反射性截瘫。脑脊液检查显示淋巴细胞增多、脑脊液蛋白显著升高和脑脊液低糖。脊髓活检标本显示髓内肉芽肿含有抗酸杆菌。该患者接受了抗结核药物治疗,神经功能缺损未进展。他在首次发病八个月后死于肺炎克雷伯菌肾盂肾炎和败血症。分枝杆菌性脊膜脊髓炎是目前已知的唯一一种对特定治疗有反应的与获得性免疫缺陷综合征相关的脊髓病。

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Mycobacterial meningomyelitis associated with human immunodeficiency virus infection.与人类免疫缺陷病毒感染相关的分枝杆菌性脑脊膜炎
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