巴拿马库纳美洲印第安人中美芬妥英的羟基化作用
Mephenytoin hydroxylation in the Cuna Amerindians of Panama.
作者信息
Inaba T, Jorge L F, Arias T D
机构信息
Department of Pharmacology, Faculty of Medicine, University of Toronto, Canada.
出版信息
Br J Clin Pharmacol. 1988 Jan;25(1):75-9. doi: 10.1111/j.1365-2125.1988.tb03284.x.
Abstract
1 Mephenytoin p(4')-hydroxylation, which is deficient in 3-5% of Caucasians, was examined in 96 Cuna Amerindians of Panama. 2 Attempts were made to exclude poor compliance with urine collection and ingestion of the drug dose since the assignment of phenotype was based upon urinary recovery of the metabolite. These involved the measurement of the urinary recovery of sparteine, added to the ingested capsule, and of the renal excretion of creatinine. 3 Of the 90 Cunas deemed to be reasonably complaint, none of them appeared to be deficient in p(4')-hydroxylation of mephenytoin.
摘要
- 对96名巴拿马库纳美洲印第安人进行了美芬妥因p(4')-羟化反应检测，约3%-5%的高加索人存在该反应缺陷。2. 由于表型的判定基于代谢物的尿回收率，因此尝试排除尿液收集不充分和药物剂量摄入不足的情况。这包括测量添加到摄入胶囊中的司巴丁的尿回收率以及肌酐的肾排泄量。3. 在被认为依从性较好的90名库纳人中，没有一人表现出美芬妥因p(4')-羟化反应缺陷。
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本文引用的文献
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Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism.高加索人中美芬妥英羟化缺乏症：一种新的氧化药物代谢多态性的频率
Clin Pharmacol Ther. 1984 Dec;36(6):773-80. doi: 10.1038/clpt.1984.256.
2
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Eur J Clin Pharmacol. 1984;26(6):753-9. doi: 10.1007/BF00541938.
3
Migration and genetic infrastructure of the Central American Guaymi and their affinities with other tribal groups.中美洲瓜伊米人的迁徙与遗传基础结构及其与其他部落群体的亲缘关系。
Am J Phys Anthropol. 1982 Jun;58(2):201-14. doi: 10.1002/ajpa.1330580213.
4
Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations.日本人群与白种人群之间在异喹胍和甲妥英羟基化遗传多态性上的种族差异。
Clin Pharmacol Ther. 1985 Oct;38(4):402-8. doi: 10.1038/clpt.1985.194.
5
Genetic polymorphism of mephenytoin p(4')-hydroxylation: difference between Orientals and Caucasians.美芬妥因p(4')-羟化作用的基因多态性：东方人与高加索人的差异。
Br J Clin Pharmacol. 1985 Apr;19(4):483-7. doi: 10.1111/j.1365-2125.1985.tb02673.x.
6
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Xenobiotica. 1986 May;16(5):379-89. doi: 10.3109/00498258609050246.
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