Groopman J E, Caiazzo T, Thomas M A, Ferriani R A, Saltzman S, Moon M, Seage G, Horsburgh C R, Mayer K
Department of Medicine, New England Deaconess Hospital/Harvard Medical School, Boston, MA.
Blood. 1988 Jun;71(6):1752-4.
Recently, considerable concern has been raised regarding the possibility that antibody-based screening tests for the human immunodeficiency virus (HIV) may fail to detect certain high-risk individuals for prolonged periods of time. It has been proposed that testing for HIV-related antigen may be a necessary procedure to detect such individuals. To address this issue, we longitudinally studied two groups of homosexual men: direct sexual partners of acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) patients and individuals who ultimately sero-converted. There was no evidence of prolonged infection with HIV in the absence of detectable antibody in these two groups. It appears at this time that, even among subjects at very high risk for HIV infection, currently available antibody-based assays are sufficient to identify infected individuals.
最近，人们对人类免疫缺陷病毒（HIV）基于抗体的筛查试验可能在较长时间内无法检测出某些高危个体的可能性提出了相当大的关注。有人提出检测HIV相关抗原可能是检测此类个体的必要程序。为了解决这个问题，我们对两组同性恋男性进行了纵向研究：获得性免疫缺陷综合征（AIDS）或AIDS相关复合征（ARC）患者的直接性伴侣以及最终血清转化的个体。在这两组中，没有证据表明在没有可检测到的抗体的情况下会长期感染HIV。目前看来，即使在HIV感染风险非常高的受试者中，目前可用的基于抗体的检测方法也足以识别受感染的个体。
