美国成年人中，无论是否有近期癌症诊断，吸烟与物质使用障碍的关联。
Association of Cigarette Use and Substance Use Disorders among US Adults with and without a Recent Diagnosis of Cancer.
机构信息
Tobacco Research and Treatment Center, Division of General Internal Medicine, Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.
出版信息
Curr Oncol. 2020 Dec 12;28(1):86-93. doi: 10.3390/curroncol28010011.
BACKGROUND
Few studies have examined substance use disorders (SUDs) in cancer patients and it is unclear whether SUDs differentially impact cigarette smoking in patients with vs. without cancer. This study used epidemiological data to estimate current cigarette smoking prevalence and quit ratios among US adults with and without SUDs by cancer status.
METHODS
Data were drawn from the 2015-2018 National Survey on Drug Use and Health ( = 170,111). Weighted current smoking prevalence and quit ratios were estimated across survey years by SUDs (with vs. without) and by cancer status (with vs. without).
RESULTS
Among those with cancer, current smoking prevalence was higher for those with vs. without SUDs (47% vs. 13%, < 0.001) and quit ratios lower for those with vs. without SUDs (45% vs. 71%, = 0.002). A similar pattern was observed in adults without cancer, with higher smoking prevalence (56% vs. 21%, < 0.001) and lower quit ratios (23% vs. 51%, < 0.001) observed for those with vs. without SUDs, respectively. In adjusted logistic regressions, the SUD × cancer status interaction was not significant for smoking prevalence or quit ratios (AOR = 1.2; 95% CI: 0.7, 2.1, = 0.56; AOR = 1.0; 95% CI: 0.5, 2.0, = 0.91, respectively), though smoking prevalence was lower and quit ratios higher for adults with vs. without cancer ( < 0.05).
CONCLUSIONS
Among US adults with and without cancer, individuals with SUDs evidenced higher cigarette smoking and lower quit ratios than those without SUDs. Addressing SUDs and their impact on smoking cessation is critical in cancer patients with implications for improving health and treatment outcomes.
背景
很少有研究检查癌症患者的物质使用障碍（SUDs），也不清楚 SUDs 是否会对患有癌症和未患有癌症的患者的吸烟行为产生不同的影响。本研究使用流行病学数据来估计美国有和没有 SUDs 的癌症患者的当前吸烟流行率和戒烟率。
方法
数据来自 2015-2018 年全国药物使用与健康调查（n=170111）。根据 SUDs（有 vs. 无）和癌症状态（有 vs. 无），对调查年度的加权当前吸烟流行率和戒烟率进行了估计。
结果
在患有癌症的人群中，有 SUDs 的人的当前吸烟率高于没有 SUDs 的人（47% vs. 13%，<0.001），有 SUDs 的人的戒烟率低于没有 SUDs 的人（45% vs. 71%，=0.002）。在没有癌症的成年人中也观察到了类似的模式，有 SUDs 的人的吸烟率更高（56% vs. 21%，<0.001），戒烟率更低（23% vs. 51%，<0.001）。在调整后的逻辑回归中，SUD×癌症状态交互项对吸烟流行率或戒烟率没有显著影响（优势比=1.2；95%可信区间：0.7，2.1，=0.56；优势比=1.0；95%可信区间：0.5，2.0，=0.91，分别），尽管有癌症的成年人的吸烟率较低，戒烟率较高（<0.05）。
结论
在有和没有癌症的美国成年人中，有 SUDs 的人比没有 SUDs 的人吸烟更多，戒烟率更低。解决 SUDs 及其对戒烟的影响对于癌症患者至关重要，这对改善健康和治疗结果具有重要意义。
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