5-羟色胺通过兔膀胱副交感神经节中的5-HT1A受体亚型抑制胆碱能传递。

5-hydroxytryptamine inhibits cholinergic transmission through 5-HT1A receptor subtypes in rabbit vesical parasympathetic ganglia.

作者信息

Nishimura T, Tokimasa T, Akasu T

机构信息

Department of Physiology, Kurume University School of Medicine, Japan.

出版信息

Brain Res. 1988 Mar 1;442(2):399-402. doi: 10.1016/0006-8993(88)91534-x.

DOI:10.1016/0006-8993(88)91534-x

PMID:3370457

Abstract

Intracellular recordings were made from parasympathetic neurons of the rabbit vesical pelvic ganglia (VPG) maintained in vitro. 5-Hydroxytryptamine (5-HT) inhibited cholinergic transmission in the VPG by reducing the fast excitatory postsynaptic potential (EPSP) evoked by stimulations of pelvic nerves. 8-Hydroxy-2-(di-n-propyl-amino) tetralin hydrochloride mimicked the inhibitory effect of 5-HT on the ganglionic transmission. 5-HT-induced inhibition of the fast EPSP was antagonized by spiperone. The results suggest that 5-HT1A receptor subtypes mediate the inhibition of cholinergic transmission in the rabbit VPG.

摘要

对体外培养的兔膀胱盆神经节（VPG）中的副交感神经元进行细胞内记录。5-羟色胺（5-HT）通过降低盆神经刺激诱发的快速兴奋性突触后电位（EPSP）来抑制VPG中的胆碱能传递。盐酸8-羟基-2-（二正丙基氨基）四氢萘模拟了5-HT对神经节传递的抑制作用。5-HT诱导的快速EPSP抑制被螺哌隆拮抗。结果表明，5-HT1A受体亚型介导了兔VPG中胆碱能传递的抑制。