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1
Activation of 5-HT3 receptor subtypes causes rapid excitation of rabbit parasympathetic neurones.5-羟色胺3型受体亚型的激活会导致家兔副交感神经元快速兴奋。
Br J Pharmacol. 1987 Jul;91(3):453-5. doi: 10.1111/j.1476-5381.1987.tb11236.x.
2
Neuronal 5-HT receptors in the periphery.外周的神经元5-羟色胺受体。
Neuropharmacology. 1984 Dec;23(12B):1473-86. doi: 10.1016/0028-3908(84)90091-1.
3
5-hydroxytryptamine inhibits cholinergic transmission through 5-HT1A receptor subtypes in rabbit vesical parasympathetic ganglia.5-羟色胺通过兔膀胱副交感神经节中的5-HT1A受体亚型抑制胆碱能传递。
Brain Res. 1988 Mar 1;442(2):399-402. doi: 10.1016/0006-8993(88)91534-x.
4
Release of endogenous dopamine by stimulation of 5-hydroxytryptamine3 receptors in rat striatum.通过刺激大鼠纹状体中的5-羟色胺3受体释放内源性多巴胺。
J Pharmacol Exp Ther. 1989 Dec;251(3):803-9.
5
Pharmacological and functional analysis of a novel serotonin receptor in the rat hippocampus.大鼠海马中一种新型5-羟色胺受体的药理学与功能分析
Eur J Pharmacol. 1990 Jul 17;182(3):441-56. doi: 10.1016/0014-2999(90)90041-4.
6
Effects of 5-HT3 receptor antagonists on 5-HT and nicotinic depolarizations in guinea-pig submucosal neurones.5-羟色胺3受体拮抗剂对豚鼠黏膜下神经元中5-羟色胺和烟碱去极化的影响。
Br J Pharmacol. 1990 Apr;99(4):840-4. doi: 10.1111/j.1476-5381.1990.tb13017.x.
7
Participation of a cholinergic mechanism in 5-hydroxytryptamine (5-HT)3 and 5-HT4 receptor-mediated stimulation of gastric emptying in rats.胆碱能机制参与5-羟色胺（5-HT）3和5-HT4受体介导的大鼠胃排空刺激作用。
Arzneimittelforschung. 1997 Nov;47(11):1242-6.
8
Which type of 5-hydroxytryptamine receptor mediates relaxation of the longitudinal muscle of guinea pig proximal colon in vitro?哪种5-羟色胺受体介导豚鼠近端结肠纵行肌在体外的舒张？
Methods Find Exp Clin Pharmacol. 1996 Sep;18(7):421-30.
9
Electrophysiological characterization of functionally distinct 5-hydroxytryptamine receptors on guinea-pig submucous plexus.豚鼠黏膜下神经丛中功能不同的5-羟色胺受体的电生理特性
Neuroscience. 1988 Jan;24(1):283-95. doi: 10.1016/0306-4522(88)90331-4.
10
The influence of 5-hydroxytryptamine agonists and antagonists on identified sympathetic preganglionic neurones in the rat, in vivo.5-羟色胺激动剂和拮抗剂对大鼠体内已鉴定的交感神经节前神经元的影响。
Br J Pharmacol. 1990 Apr;99(4):667-72. doi: 10.1111/j.1476-5381.1990.tb12987.x.

引用本文的文献

1
Activation of serotonin 3 receptors changes in vivo auditory responses in the mouse inferior colliculus.血清素3受体的激活会改变小鼠下丘的体内听觉反应。
Hear Res. 2009 May;251(1-2):29-38. doi: 10.1016/j.heares.2009.02.006. Epub 2009 Feb 21.
2
Transient and long-lasting actions of 5-HT on rat dentate gyrus neurones in vitro.5-羟色胺对体外培养的大鼠齿状回神经元的短暂和持久作用
J Physiol. 1994 Dec 15;481 ( Pt 3)(Pt 3):629-39. doi: 10.1113/jphysiol.1994.sp020469.
3
5-Hydroxytryptamine acts at 5-HT2 receptors to decrease potassium conductance in rat nucleus accumbens neurones.5-羟色胺作用于5-HT2受体，以降低大鼠伏隔核神经元的钾离子电导。
J Physiol. 1989 Oct;417:1-12. doi: 10.1113/jphysiol.1989.sp017786.
4
Endothelin modulates calcium channel current in neurones of rabbit pelvic parasympathetic ganglia.内皮素调节兔盆腔副交感神经节神经元中的钙通道电流。
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5
Blockade of 5-HT3 receptor-mediated currents in dissociated frog sensory neurones by benzoxazine derivative, Y-25130.苯并恶嗪衍生物Y-25130对离体青蛙感觉神经元中5-HT3受体介导电流的阻断作用
Br J Pharmacol. 1992 Nov;107(3):853-7. doi: 10.1111/j.1476-5381.1992.tb14536.x.

本文引用的文献

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Multiple actions of 5-hydroxytryptamine on myenteric neurones of the guinea-pig ileum.5-羟色胺对豚鼠回肠肌间神经元的多种作用。
J Physiol. 1980 Jul;304:459-70. doi: 10.1113/jphysiol.1980.sp013336.
2
5-Hydroxytryptamine receptors of visceral primary afferent neurones on rabbit nodose ganglia.兔结状神经节内脏初级传入神经元的5-羟色胺受体
J Physiol. 1982 Feb;323:543-67. doi: 10.1113/jphysiol.1982.sp014091.
3
Depolarizing responses recorded from nodose ganglion cells of the rabbit evoked by 5-hydroxytryptamine and other substances.由5-羟色胺和其他物质诱发的家兔结节神经节细胞的去极化反应。
Neuropharmacology. 1982 Jan;21(1):31-40. doi: 10.1016/0028-3908(82)90207-6.
4
Neuronal 5-HT receptors in the periphery.外周的神经元5-羟色胺受体。
Neuropharmacology. 1984 Dec;23(12B):1473-86. doi: 10.1016/0028-3908(84)90091-1.
5
Cholinergic transmission in cat parasympathetic ganglia.猫副交感神经节中的胆碱能传递。
J Physiol. 1982 Nov;332:473-86. doi: 10.1113/jphysiol.1982.sp014425.
6
The facilitatory actions of 5-hydroxytryptamine and bradykinin in the superior cervical ganglion of the rabbit.5-羟色胺和缓激肽对兔颈上神经节的易化作用。
Br J Pharmacol. 1974 Aug;51(4):521-31. doi: 10.1111/j.1476-5381.1974.tb09670.x.
7
5-HT hyperpolarization of bullfrog sympathetic ganglion cell membrane.牛蛙交感神经节细胞膜的5-羟色胺超极化
Experientia. 1973 Nov 15;29(11):1370-2. doi: 10.1007/BF01922825.
8
Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs.5-羟色胺M受体亚型的鉴定及其被一类新型药物的特异性阻断
Nature. 1985;316(6024):126-31. doi: 10.1038/316126a0.
9
The depolarizing action of 5-hydroxytryptamine on rabbit vagal afferent and sympathetic neurones in vitro and its selective blockade by ICS 205-930.5-羟色胺对兔迷走传入神经和交感神经元的去极化作用及其被ICS 205-930的选择性阻断。
Br J Pharmacol. 1986 Jun;88(2):485-94. doi: 10.1111/j.1476-5381.1986.tb10227.x.
10
Excitatory 5-hydroxytryptamine receptors in the cat urinary bladder are of the M- and 5-HT2-type.猫膀胱中的兴奋性5-羟色胺受体属于M型和5-HT2型。
J Auton Pharmacol. 1985 Jun;5(2):101-7. doi: 10.1111/j.1474-8673.1985.tb00110.x.

5-羟色胺3型受体亚型的激活会导致家兔副交感神经元快速兴奋。

Activation of 5-HT3 receptor subtypes causes rapid excitation of rabbit parasympathetic neurones.

作者信息

Akasu T, Hasuo H, Tokimasa T

出版信息

Br J Pharmacol. 1987 Jul;91(3):453-5. doi: 10.1111/j.1476-5381.1987.tb11236.x.

DOI:10.1111/j.1476-5381.1987.tb11236.x
PMID:3607365
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1853566/
Abstract

Intracellular recordings were made from parasympathetic neurones of the rabbit vesical pelvic ganglia maintained in vitro. 5-Hydroxytryptamine (5-HT) caused a membrane depolarization which was antagonized by ICS 205-930 ([3 alpha-tropanyl]-1H-indole-3-carboxylic acid ester) but not by methysergide. ICS 205-930 caused a parallel shift to the right of the dose-response curve for 5-HT. These results suggest that the 5-HT3 receptor is involved in the membrane depolarization.

摘要

对体外培养的兔膀胱盆神经节副交感神经元进行细胞内记录。5-羟色胺（5-HT）引起膜去极化，该去极化被ICS 205-930（[3α-托烷基]-1H-吲哚-3-羧酸酯）拮抗，但不被麦角酰二乙胺拮抗。ICS 205-930使5-HT的剂量-反应曲线向右平行移动。这些结果表明5-HT3受体参与了膜去极化。