5-羟色胺3型受体亚型的激活会导致家兔副交感神经元快速兴奋。
Activation of 5-HT3 receptor subtypes causes rapid excitation of rabbit parasympathetic neurones.
作者信息
Akasu T, Hasuo H, Tokimasa T
出版信息
Br J Pharmacol. 1987 Jul;91(3):453-5. doi: 10.1111/j.1476-5381.1987.tb11236.x.
Abstract
Intracellular recordings were made from parasympathetic neurones of the rabbit vesical pelvic ganglia maintained in vitro. 5-Hydroxytryptamine (5-HT) caused a membrane depolarization which was antagonized by ICS 205-930 ([3 alpha-tropanyl]-1H-indole-3-carboxylic acid ester) but not by methysergide. ICS 205-930 caused a parallel shift to the right of the dose-response curve for 5-HT. These results suggest that the 5-HT3 receptor is involved in the membrane depolarization.
摘要
对体外培养的兔膀胱盆神经节副交感神经元进行细胞内记录。5-羟色胺（5-HT）引起膜去极化，该去极化被ICS 205-930（[3α-托烷基]-1H-吲哚-3-羧酸酯）拮抗，但不被麦角酰二乙胺拮抗。ICS 205-930使5-HT的剂量-反应曲线向右平行移动。这些结果表明5-HT3受体参与了膜去极化。
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