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[子宫内膜异位症疼痛的管理:基于分期的治疗策略及临床经验]

[Management of endometriosis pain : Stage-based treatment strategies and clinical experience].

作者信息

Mechsner Sylvia

机构信息

Klinik für Gynäkologie, Endometriosezentrum Charité, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland.

出版信息

Schmerz. 2021 Jun;35(3):159-171. doi: 10.1007/s00482-021-00543-8. Epub 2021 Mar 11.

Abstract

BACKGROUND

Endometriosis is associated with various types of intense pain. In addition to nociceptive pain, there is also a nociplastic reaction with central sensitization. Atypical symptoms such as acyclic lower abdominal pain, radiating pain, non-specific bladder and intestinal complaints or even depression are frequent as are classic cyclical complaints such as severe dysmenorrhea, cyclical lower abdominal pain, dyspareunia, dysuria and dyschezia. In cases of a diverse range of symptoms, patients often consult not just gynecologists but specialists from other disciplines (e.g., internal medicine, gastroenterology, orthopedics, pain therapy, psychology).

AIMS

Overview about the pathophysiology and complexity of the disease and the resulting treatment options. A multimodal interdisciplinary concept might be able to take into consideration all aspects of the complex disease.

METHODS

Interdisciplinary concepts should be involved in the treatment of endometriosis patients along with hormonal and surgical therapy, which are generally under the supervision of a gynecologist. Pain management, dietary changes, psychological support, as well as physiotherapy should be included. The present article is intended to provide an overview of possible treatment strategies for chronic, symptomatic endometriosis.

CONCLUSION

The use of multimodal treatment strategies regarding the complex pathophysiological aspects of this disease might be helpful in significantly improving the quality of life of endometriosis patients.

摘要

背景

子宫内膜异位症与多种剧烈疼痛相关。除伤害性疼痛外,还存在伴有中枢敏化的神经可塑性反应。非典型症状如非周期性下腹痛、放射痛、非特异性膀胱和肠道不适甚至抑郁很常见,典型的周期性症状如严重痛经、周期性下腹痛、性交困难、排尿困难和排便困难也很常见。在症状多样的情况下,患者不仅经常咨询妇科医生,还会咨询其他学科的专家(如内科、胃肠病学、骨科、疼痛治疗、心理学)。

目的

概述该疾病的病理生理学和复杂性以及由此产生的治疗选择。多模式跨学科概念或许能够考虑到这种复杂疾病的所有方面。

方法

子宫内膜异位症患者的治疗应采用跨学科概念,并结合激素和手术治疗,这些通常在妇科医生的监督下进行。应包括疼痛管理、饮食改变、心理支持以及物理治疗。本文旨在概述慢性症状性子宫内膜异位症可能的治疗策略。

结论

针对该疾病复杂病理生理方面采用多模式治疗策略可能有助于显著提高子宫内膜异位症患者的生活质量。

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