Bouaziz Jerome, Bar On Alexandra, Seidman Daniel S, Soriano David
Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Ramat-Gan, Israel.
Department of Urology, The Chaim Sheba Medical Center, Ramat-Gan, Israel.
Cannabis Cannabinoid Res. 2017 Apr 1;2(1):72-80. doi: 10.1089/can.2016.0035. eCollection 2017.
Patients with endometriosis often suffer from diffuse and poorly localized severe pain. The current pain management strategies include medical and hormonal therapy, as well as surgery. Medical management of pain is often insufficient and is associated with high rate of recurrence. Better pain management is therefore of urgent need. Among the various candidates, the endocannabinoid system (ECS) has recently emerged as a relevant pharmacological target for the management of endometriosis-related pain. A computerized literature search was performed to identify relevant studies combining the keywords "endometriosis," "endocannabinoid," "cannabinoid receptor," "THC," and "pain mechanisms." This review describes the multiple and complex pain mechanisms associated with endometriosis. Current data and theories concerning the link between the ECS and pain management for endometriosis patients are presented. Finally, we will discuss which aspects of endometriosis-associated pain can be targeted by modulation of the ECS.
子宫内膜异位症患者常遭受弥漫性且定位不佳的严重疼痛。当前的疼痛管理策略包括药物和激素治疗以及手术。疼痛的药物管理往往不足，且复发率高。因此，迫切需要更好的疼痛管理。在各种候选方案中，内源性大麻素系统（ECS）最近已成为管理子宫内膜异位症相关疼痛的一个相关药理学靶点。进行了计算机化文献检索，以识别结合关键词“子宫内膜异位症”、“内源性大麻素”、“大麻素受体”、“四氢大麻酚”和“疼痛机制”的相关研究。本综述描述了与子宫内膜异位症相关的多种复杂疼痛机制。介绍了有关ECS与子宫内膜异位症患者疼痛管理之间联系的当前数据和理论。最后，我们将讨论通过调节ECS可以针对子宫内膜异位症相关疼痛的哪些方面。
