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确保在 COVID 大流行期间持续开展儿科肝脏移植服务的方案及令人鼓舞的结果。

Protocol to ensure continued pediatric liver transplantation service during the COVID pandemic and the encouraging outcomes.

机构信息

Centre for Liver and Biliary Sciences, Max Super Speciality Hospital, New Delhi, India.

出版信息

Pediatr Transplant. 2021 May;25(3):e13991. doi: 10.1111/petr.13991. Epub 2021 Mar 11.

DOI:10.1111/petr.13991
PMID:33704869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8206749/
Abstract

Coronavirus disease 2019 is a global pandemic, and to deal with the unexpected, enormous burden on healthcare system, liver transplantation (LT) services have been suspended in many centers. Development of robust and successful protocols in preventing the disease among the recipients, donors and healthcare workers would help in re-starting the LT programs. We adapted a protocol at our center, which is predominantly a living donor liver transplant center based in north India, and continued the service as the pandemic unfolded and peaked in India with good results and shared the experience of the same. Between March 24 and June 7, 2020, during the government-enforced public curfew-"lockdown"-7 children received LT. The protocols of infection control were drafted in our team by local customization of published guidelines. The number of pediatric LT done during the lockdown period in 2020 was similar to that done in corresponding pre-COVID period in 2019. The outcomes were of 100% survival, and none of recipients developed COVID. One potential donor was asymptomatic positive for COVID, responded well to conservative treatment, and was later accepted as a donor. LT program during the COVID pandemic can successfully function after putting in place standard protocols for infection control. These can be implemented with minimal extra involvement of healthcare infrastructure, hence without diversion of resources from COVID management. In conclusion, pediatric liver transplantation services can be continued amid COVID-19 pandemic after establishing a properly observed protocol with minimum additional resources.

摘要

2019 年冠状病毒病是一场全球性大流行,为应对医疗系统面临的意外、巨大负担,许多中心暂停了肝移植(LT)服务。制定预防受者、供者和医护人员感染的强有力和成功方案,将有助于重新启动 LT 项目。我们在自己的中心采用了一项方案,该中心主要是一家位于印度北部的活体供者肝移植中心,并在印度大流行期间展开服务,取得了良好的效果,现分享相关经验。2020 年 3 月 24 日至 6 月 7 日,在政府实施的公众宵禁——“封锁”期间,有 7 名儿童接受了 LT。感染控制方案是由我们团队通过对已发表指南的本地化定制而起草的。2020 年封锁期间进行的小儿 LT 数量与 2019 年同期 COVID 前时期相似。结果为 100%存活率,没有受者感染 COVID。一名潜在供者无症状 COVID 检测呈阳性,对保守治疗反应良好,后来被接受为供者。在实施感染控制标准方案后,COVID 大流行期间 LT 项目可以成功运行。这些方案可以在不增加医疗基础设施额外投入的情况下实施,因此不会从 COVID 管理中转移资源。总之,在建立经过适当观察的方案并投入最少的额外资源的情况下,可以在 COVID-19 大流行期间继续开展小儿肝移植服务。

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Pediatr Transplant. 2021 May;25(3):e13991. doi: 10.1111/petr.13991. Epub 2021 Mar 11.
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本文引用的文献

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Child with liver transplant recovers from COVID-19 infection. A case report.接受肝移植的儿童从新冠病毒感染中康复。病例报告。
Arch Pediatr. 2020 Jul;27(5):275-276. doi: 10.1016/j.arcped.2020.05.004. Epub 2020 May 6.
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Immediate impact of COVID-19 on transplant activity in the Netherlands.COVID-19 对荷兰器官移植活动的直接影响。
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Kidney transplant programmes during the COVID-19 pandemic.2019冠状病毒病大流行期间的肾移植项目。
Lancet Respir Med. 2020 May;8(5):e39. doi: 10.1016/S2213-2600(20)30182-X. Epub 2020 Apr 16.
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Clinical Best Practice Advice for Hepatology and Liver Transplant Providers During the COVID-19 Pandemic: AASLD Expert Panel Consensus Statement.《COVID-19 大流行期间肝病学和肝移植提供者的临床最佳实践建议:AASLD 专家小组共识声明》。
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Liver transplantation and COVID-19 (Coronavirus) infection: guidelines of the liver transplant Society of India (LTSI).肝移植与 COVID-19(冠状病毒)感染:印度肝移植学会(LTSI)指南。
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Fair Allocation of Scarce Medical Resources in the Time of Covid-19.新冠疫情期间稀缺医疗资源的公平分配
N Engl J Med. 2020 May 21;382(21):2049-2055. doi: 10.1056/NEJMsb2005114. Epub 2020 Mar 23.
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COVID-19: A global transplant perspective on successfully navigating a pandemic.COVID-19:从全球移植角度成功应对大流行。
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