Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Beheshti University of Medical Sciences.
Faculty of Veterinary Medicine, Department of Surgery and Radiology, University of Tehran, Tehran.
J Craniofac Surg. 2021;32(2):794-798. doi: 10.1097/SCS.0000000000007003.
Alternative treatment approaches to improve the regeneration ability of damaged peripheral nerves are currently under investigation. The aim of the current study was to evaluate the effects of leucocyte/platelet-rich fibrin (L-PRF) with or without a collagen membrane as a supporter on crushed sciatic nerve healing in a rat model. Recovery of motor function and electrophysiologic measurements were evaluated at 4 weeks postoperatively. The whole number of myelinated axons, peripheral nerve axon density, average nerve fiber diameter (μm), and G-ratio were analyzed and compered among the groups. Functional, electrophysiological, and histological evaluations showed no significant difference among the groups with the exception of the L-PRF with collagen membrane groups that showed relatively positive effects on the functional and histological nerve recovery. In addition, the collagen membrane with L-PRF can be effect in nerve regeneration.
目前正在研究改善受损周围神经再生能力的替代治疗方法。本研究旨在评估富白细胞/血小板纤维蛋白（L-PRF）联合或不联合胶原膜作为支架对大鼠挤压坐骨神经损伤愈合的影响。术后 4 周评估运动功能恢复和电生理测量。分析并比较各组有髓神经轴突总数、周围神经轴突密度、平均神经纤维直径（μm）和 G 比值。功能、电生理和组织学评估显示各组之间无显著差异，但 L-PRF 联合胶原膜组在功能和组织学神经恢复方面显示出相对积极的效果。此外，胶原膜联合 L-PRF 可能对神经再生有效。
