Zhao Ying, Dong Chen, Fan Liumeizi, Lei Ting, Ge Xin, Yu Zhou, Hu Sheng
Department of Anesthesiology and Perioperative Medicine, Xi'an People's Hospital (Xi'an Fourth Hospital), Northwest University, Xi'an, Shaanxi Province, China.
Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Indian J Plast Surg. 2024 Sep 11;57(5):356-363. doi: 10.1055/s-0044-1779478. eCollection 2024 Oct.
A rapid expansion of study on platelet-rich fibrin (PRF) has gained more attention in the subject. In this study, bibliometrics were used to assess the outputs and trends of relevant PRF studies. An in-depth analysis of the publication patterns and progress in PRF research worldwide was conducted for the purpose of filling in this research gap. The analysis included 946 papers sourced from Web of Science that included 842 original articles and 104 reviews. A number of factors including country/region, institution, journal, and author were taken into account. Research on PRF development trends was mapped using the frequency of keywords. In terms of the total number of publications, China ranked first with 199 papers, whereas the United States ranked first on the H-index with 37. PRF is an active research area in stomatology and craniomaxillofacial surgery. Keywords provided by the authors were designated to three clusters: red, green, and blue. "Growth factor," "platelet-rich plasma," and "bone regeneration" were the most frequent keywords in each cluster, which reflect the current interests in corresponding fields. Bone regeneration post-dental extractions is one of the main application directions in the field of oral and maxillofacial surgery. "Membrane," "injectable PRF (I-PRF)," "case report," and "advanced PRF (A-PRF)" were relative recent keywords in all clusters, indicating that manufacturing processes and new applications are promising research hotspots in the field. In the future, the applications of modified PRF, such as I-PRF, are promising research hotspots. Moreover, strict randomized controlled trials on PRF deserve more attention. The results of this analysis may be helpful for all scholars seeking to expand researches and innovations in the field of PRF.
富血小板纤维蛋白（PRF）研究的迅速扩展在该领域受到了更多关注。在本研究中，采用文献计量学方法评估PRF相关研究的产出和趋势。为填补这一研究空白，对全球PRF研究的发表模式和进展进行了深入分析。
该分析纳入了来自科学网的946篇论文，其中包括842篇原创文章和104篇综述。考虑了包括国家/地区、机构、期刊和作者在内的诸多因素。利用关键词出现频率绘制PRF发展趋势研究图谱。
在出版物总数方面，中国以199篇论文位居第一，而美国以H指数37位居第一。PRF是口腔医学和颅颌面外科的一个活跃研究领域。作者提供的关键词被分为三个集群：红色、绿色和蓝色。“生长因子”“富血小板血浆”和“骨再生”是每个集群中出现频率最高的关键词，反映了当前对相应领域的关注。拔牙后骨再生是口腔颌面外科领域的主要应用方向之一。“膜”“可注射PRF（I-PRF）”“病例报告”和“高级PRF（A-PRF）”是所有集群中相对较新的关键词，表明制造工艺和新应用是该领域有前景的研究热点。
未来，I-PRF等改良PRF的应用是有前景的研究热点。此外，关于PRF的严格随机对照试验值得更多关注。该分析结果可能对所有寻求在PRF领域拓展研究和创新的学者有所帮助。
