Department of Neuroscience, and Reproductive Sciences and Odontostomatology, Maxillofacial Surgery, Section.
Department of Neuroscience, and Reproductive Sciences and Odontostomatology, Ophthalmology Section, Federico II University of Naples, Naples, Italy.
J Craniofac Surg. 2021;32(2):e114-e116. doi: 10.1097/SCS.0000000000006819.
The aim of this study was to report management and outcomes of patients in which conjunctival carcinomas arose in the anophthalmic socket.
The authors retrospectively analyzed the data of patients which presented the anophthalmic socket after surgery. The clinical records of 4 patients with histological diagnosis of conjunctival carcinoma in the anophthalmic socket, referred to our Department, between January 2014 and December 2019 was collected.
The study included 4 men (median age 58 years). A previous enucleation surgery had been performed in all patients due to previous ocular trauma for three patients (Case 1, 3, and 4) and due to a retinoblastoma for 1 patient (Case 2). All patients underwent surgical excision of the lesion and only 1 patient (case 3) underwent orbital exenteration due to the high-grade of the cancer. The most common tumor was the squamous cell carcinoma (2 cases) followed by 1 case of high-grade mucoepidermoid carcinoma and 1 case of carcinoma in situ. Systemic work-up was performed for all the patients. Conjunctival TNM, according to the American Joint Committee on Cancer TNM staging system was used to stage the lesions. The median follow-up time was 15 months.
Considering the severity and rarity of these tumors, a careful ophthalmological examination of the cavity and a correct revision of the prosthesis should be mandatory in order to ensure the elimination of any macro and microscopic irregularities that can then in the long-term cause chronic inflammation of the tissues and consequently promote the growth of carcinomas.
本研究旨在报告眼窝内结膜癌患者的治疗和预后情况。
作者回顾性分析了手术后眼窝内出现结膜癌患者的资料。收集了 2014 年 1 月至 2019 年 12 月期间，因眼窝内结膜癌就诊于我院的 4 例患者的临床资料，所有患者均经组织学诊断确诊。
本研究纳入了 4 例男性患者（中位年龄 58 岁）。所有患者均因先前的眼外伤行眼球摘除术（3 例，分别为病例 1、3 和 4），1 例因视网膜母细胞瘤行眼球摘除术（病例 2）。所有患者均行病变切除术，仅 1 例（病例 3）因癌症分级较高而行眼眶内容剜除术。最常见的肿瘤是鳞状细胞癌（2 例），其次是高级别黏液表皮样癌（1 例）和原位癌（1 例）。所有患者均进行了全身检查。根据美国癌症联合委员会 TNM 分期系统，采用结膜 TNM 分期来分期病变。中位随访时间为 15 个月。
鉴于这些肿瘤的严重程度和罕见性，应仔细检查眼窝并正确修正义眼，以消除任何可能导致长期组织慢性炎症的宏观和微观不规则，从而促进癌的生长。
