Ha Jeong Hyun, Arora Jagmeet S, Sayadi Jamasb J, Khattab Nada R, Francis Shannon D, Johnstone Thomas M, Jang Yeonji, Lee Gordon K
Interdisciplinary Program of Medical Informatics, Seoul National University College of Medicine, Seoul, South Korea.
Plastic and Reconstructive Surgery, CHA Gangnam Medical Center, CHA University School of Medicine, Pocheon, South Korea.
BMC Cancer. 2025 Jan 28;25(1):167. doi: 10.1186/s12885-024-13422-z.
While prosthesis-associated malignancies have been acknowledged, awareness among surgeons and patients in the ophthalmologic field remains limited, despite the frequent occurrence of prosthesis-related surgeries. We aim to address this gap through a scoping review of malignancies following ophthalmologic surgeries involving various foreign device/prosthesis/implants.
Following PRISMA guidelines, we conducted a review using PubMed and Embase for studies on cancer and ophthalmic prostheses/implants. The final selection of articles for the ophthalmology aspect underwent rigorous investigation.
We analyzed 30 studies, identifying 41 cases of malignancies following interventions involving orbital foreign devices. Foreign devices linked to malignancies included scleral shells, orbital implants, scleral buckles, encircling bands, and gold plates. Ocular surface squamous neoplasm was most common, with 29 cases. Other malignancies observed were pleomorphic sarcoma, synovial sarcoma, marginal zone B-cell lymphoma, sebaceous carcinoma, malignant melanoma, adenocarcinoma, and metastatic lung adenocarcinoma. These malignancies varied in characteristics and demographics, with some showing metastasis or local invasion. The median time to tumor development was 40 years.
This study highlights a spectrum of malignancies following orbital foreign device procedures and suggests a potential association between different types of orbital foreign devices and malignancies. Future studies, including well-designed epidemiologic studies and scientific experiments, are warranted to elucidate the causal relationship.
尽管与假体相关的恶性肿瘤已得到认可，但在眼科领域，尽管与假体相关的手术频繁发生，但外科医生和患者的认识仍然有限。我们旨在通过对涉及各种外来装置/假体/植入物的眼科手术后的恶性肿瘤进行范围审查来填补这一空白。
遵循PRISMA指南，我们使用PubMed和Embase对关于癌症和眼科假体/植入物的研究进行了综述。对眼科方面文章的最终选择进行了严格审查。
我们分析了30项研究，确定了41例涉及眼眶外来装置干预后的恶性肿瘤病例。与恶性肿瘤相关的外来装置包括巩膜壳、眼眶植入物、巩膜扣带、环扎带和金片。眼表鳞状肿瘤最为常见，有29例。观察到的其他恶性肿瘤包括多形性肉瘤、滑膜肉瘤、边缘区B细胞淋巴瘤、皮脂腺癌、恶性黑色素瘤、腺癌和转移性肺腺癌。这些恶性肿瘤在特征和人口统计学方面各不相同，有些表现出转移或局部侵袭。肿瘤发生的中位时间为40年。
本研究强调了眼眶外来装置手术后的一系列恶性肿瘤，并表明不同类型的眼眶外来装置与恶性肿瘤之间可能存在关联。有必要开展进一步研究，包括精心设计的流行病学研究和科学实验，以阐明因果关系。
