群体特异性蛋白质标志物：梅毒而非人类免疫缺陷病毒感染的可能指标。
The group-specific protein marker: a possible indicator of syphilis, not human immunodeficiency virus infection.
作者信息
Pollard D R, Gill P, Day A
机构信息
Bureau of Microbiology, Department of National Health and Welfare, Ottawa, Tunney's Pasture, Ont.
出版信息
CMAJ. 1988 Jun 1;138(11):1013-5.
We wished to compare the frequency of group-specific (Gc) phenotypes in the general population with that in people with human immunodeficiency virus (HIV) infection to find out whether the Gc protein is a marker for susceptibility to HIV infection. We determined the phenotype frequency in 1083 randomly selected serum samples obtained from the Canadian Influenza Survey Studies and compared it with that in 263 serum samples obtained from the Federal Centre for AIDS and the Syphilis Serology Proficiency Testing Laboratory. No association between Gc phenotype and HIV status was found. However, there was a strong association between the Gc protein 1f/1f phenotype and syphilis.
我们希望比较普通人群与人类免疫缺陷病毒（HIV）感染者中群体特异性（Gc）表型的频率，以确定Gc蛋白是否为HIV感染易感性的标志物。我们测定了从加拿大流感调查研究中随机选取的1083份血清样本中的表型频率，并将其与从联邦艾滋病和梅毒血清学能力验证实验室获得的263份血清样本中的表型频率进行比较。未发现Gc表型与HIV感染状态之间存在关联。然而，Gc蛋白1f/1f表型与梅毒之间存在强关联。
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