Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Gastroenterology and Hepatology Division, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.
Cell Host Microbe. 2021 Mar 10;29(3):318-320. doi: 10.1016/j.chom.2021.02.012.
The gut microbiota regulates intestinal immunity, but whether immune activation reciprocally alters gut commensals is unknown. In this issue of Cell Host & Microbe, Becattini et al. used a reductionist approach, incorporating gnotobiotic mouse models and multi-omics analyses, to address how gut commensals respond and adapt to acute immune activation.
肠道微生物群调节肠道免疫，但免疫激活是否会反过来改变肠道共生菌尚不清楚。在本期《Cell Host & Microbe》杂志上，Becattini 等人采用了一种简化的方法，结合无菌小鼠模型和多组学分析，来研究肠道共生菌如何对急性免疫激活做出反应和适应。
