Department of Immunobiology, University of Arizona, Tucson, AZ 85719, USA; Arizona Arthritis Center, College of Medicine, University of Arizona, Tucson, AZ 85719, USA.
Cell Host Microbe. 2021 Mar 10;29(3):325-326. doi: 10.1016/j.chom.2021.02.016.
In this COVID era, when many struggle to work remotely, methotrexate (MTX) has been doing so all along. In this issue of Cell Host & Microbe, Nayak et al. discover that MTX reduces immune activation due to off-target effects on the gut microbiota, potentially explaining MTX's anti-inflammatory effects.
在这个 COVID 时代，许多人都在努力远程工作，而甲氨蝶呤 (MTX) 一直以来都是如此。在本期《细胞宿主与微生物》中，Nayak 等人发现 MTX 通过对肠道微生物组的脱靶作用来减少免疫激活，这可能解释了 MTX 的抗炎作用。
