Department of Pathology, University of Utah School of Medicine, Division of Microbiology and Immunology, Salt Lake City, UT 84112, USA.
Department of Pathology, University of Utah School of Medicine, Division of Microbiology and Immunology, Salt Lake City, UT 84112, USA.
Cell Host Microbe. 2021 Mar 10;29(3):334-346. doi: 10.1016/j.chom.2021.02.009.
Immunoglobulin A (IgA) is the most abundant antibody at mucosal surfaces and has been the subject of many investigations involving microbiota research in the last decade. Although the classic functions of IgA include neutralization of harmful toxins, more recent investigations have highlighted an important role for IgA in regulating the composition and function of the commensal microbiota. Multiple reviews have comprehensively covered the literature that describes recent, novel mechanisms of action of IgA and development of the IgA response within the intestine. Here we focus on how the interaction between IgA and the microbiota promotes homeostasis with the host to prevent disease.
免疫球蛋白 A（IgA）是黏膜表面最丰富的抗体，在过去十年中，许多涉及微生物组研究的调查都以 IgA 为主题。虽然 IgA 的经典功能包括中和有害毒素，但最近的研究强调了 IgA 在调节共生微生物群落的组成和功能方面的重要作用。多项综述全面涵盖了描述 IgA 新作用机制和在肠道中 IgA 反应发展的文献。在这里，我们重点关注 IgA 与微生物群之间的相互作用如何促进与宿主的内稳定以预防疾病。
