Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, 510515, China.
Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, 510515, China.
Mol Immunol. 2021 Jun;134:25-33. doi: 10.1016/j.molimm.2021.02.021. Epub 2021 Mar 9.
Hair follicle (HF) is an excellent mini-model to study adult tissue regeneration, since it can regenerate itself under appropriate stress settings via interaction with niche components. Dermal macrophages, a group of heterogeneous cell populations, serve as key regulators in this microenvironment. Recent advances in phenotype identification and lineage tracing have unveiled various dermal macrophage subsets involved in stress-induced hair regeneration through different mechanisms, where HF structural integrity is impaired to varying degrees. This review summarized current knowledge regarding the distribution, sources, phenotypes of dermal macrophages in association with HF, as well as the mechanisms underlying macrophage-mediated hair regeneration in response to different internal-stress settings. Further investigation on macrophage dynamics will provide novel cell-targeting therapies for HF engineering and hair loss.
毛囊是研究成人组织再生的极佳小型模型，因为它可以通过与小生境成分的相互作用，在适当的压力环境下进行自身再生。真皮巨噬细胞是一组异质细胞群体，作为这个微环境中的关键调节因子。最近在表型鉴定和谱系追踪方面的进展揭示了各种真皮巨噬细胞亚群，它们通过不同的机制参与应激诱导的毛发再生，其中毛囊的结构完整性受到不同程度的损害。本综述总结了目前关于与毛囊相关的真皮巨噬细胞的分布、来源、表型以及在不同内部应激环境下巨噬细胞介导的毛发再生机制的知识。进一步研究巨噬细胞的动态将为毛囊工程和脱发的靶向细胞治疗提供新的途径。
