Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Exp Dermatol. 2017 Jun;26(6):505-509. doi: 10.1111/exd.13359.
Understanding the cellular interactions and molecular signals underlying hair follicle (HF) regeneration may have significant implications for restorative therapies for skin disease that diminish hair growth, whilst also serving to provide fundamental insight into the mechanisms underlying adult tissue regeneration. One of the major, yet underappreciated, players in this process is the underlying HF mesenchyme. Here, we provide an overview of a mesenchymal progenitor pool referred to as hair follicle dermal stem cells (hfDSCs), discuss their potential functions within the skin and their relationship to skin-derived precursors (SKPs), and consider unanswered questions about the function of these specialized fibroblasts. We contend that dermal stem cells provide an important reservoir of renewable dermal progenitors that may enable development of novel restorative therapies following hair loss, skin injury or disease.
了解毛囊（HF）再生的细胞相互作用和分子信号可能对恢复因皮肤疾病而减少毛发生长的疗法具有重要意义，同时也为阐明成人组织再生的机制提供了基本的见解。在这个过程中，一个主要但尚未得到充分认识的参与者是潜在的 HF 间充质。在这里，我们提供了一个称为毛囊真皮干细胞（hfDSC）的间充质祖细胞池的概述，讨论了它们在皮肤中的潜在功能及其与皮肤衍生前体细胞（SKP）的关系，并考虑了这些专门的成纤维细胞功能的未解决问题。我们认为真皮干细胞提供了一个重要的可再生真皮祖细胞库，这可能为脱发、皮肤损伤或疾病后新的恢复性治疗方法的发展提供可能。
