RNA 可逆甲基化调控染色质和转录。
Chromatin and transcriptional regulation by reversible RNA methylation.
机构信息
Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, The University of Chicago, 929 East 57 Street, Chicago, IL, 60637, USA; Howard Hughes Medical Institute, The University of Chicago, 929 East 57 Street, Chicago, IL, 60637, USA.
Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, The University of Chicago, 929 East 57 Street, Chicago, IL, 60637, USA; Howard Hughes Medical Institute, The University of Chicago, 929 East 57 Street, Chicago, IL, 60637, USA.
出版信息
Curr Opin Cell Biol. 2021 Jun;70:109-115. doi: 10.1016/j.ceb.2020.11.005. Epub 2021 Mar 9.
Dynamic RNA modifications have been a burgeoning area in the last decade since the concept of 'RNA epigenetics' was proposed [1]. N-methyladenosine (mA) is the most abundant mRNA modification in eukaryotic cells. It can be installed by 'writers', removed by 'erasers,' recognized by 'readers,' and dynamically regulate the fate of methylated RNA. Until recently, the roles of reversible RNA methylation in chromatin and transcriptional regulation were not adequately studied. We discuss the new discoveries and insights into the chromatin and transcriptional regulation by mA through two pathways: 1) effects of mA on mRNAs encoding histone modifiers and transcriptional factors; 2) mA regulation of chromatin-associated regulatory RNAs. Additionally, we provide an outlook on how the transcriptional regulation by RNA mA could add an additional critical layer to transcriptional regulation.
在过去的十年中，自从“RNA 表观遗传学”的概念被提出以来，动态 RNA 修饰已经成为一个迅速发展的领域[1]。N6-甲基腺苷（m6A）是真核细胞中最丰富的 mRNA 修饰。它可以由“writers”安装，由“erasers”去除，由“readers”识别，并动态调节甲基化 RNA 的命运。直到最近，可逆 RNA 甲基化在染色质和转录调控中的作用还没有得到充分研究。我们通过两种途径讨论了 mA 在染色质和转录调控中的新发现和见解：1）mA 对编码组蛋白修饰酶和转录因子的 mRNAs 的影响；2）mA 对染色质相关调控 RNA 的调控。此外，我们还展望了 RNA mA 的转录调控如何为转录调控增加一个额外的关键层。
Zotero 插件