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[慢性骶尾部放射性溃疡的分期修复策略]

[Staged repair strategy for chronic sacrococcygeal radiation ulcer].

作者信息

Cheng L, Du W L, Zhang Y, Chen Z, Shen Y M

机构信息

Department of Burns, Beijing Jishuitan Hospital, Beijing 100035, China.

出版信息

Zhonghua Shao Shang Za Zhi. 2021 Mar 20;37(3):225-231. doi: 10.3760/cma.j.cn501120-20210104-00003.

Abstract

To investigate the clinical effect of staged repair strategy for chronic sacrococcygeal radiation ulcer. The retrospective cohort study method was applied. Twelve patients with chronic sacrococcygeal radiation ulcer were admitted to Beijing Jishuitan Hospital from January 2010 to June 2020, including 7 males and 5 females, aged 38-74 years. The thorough debridement was performed in the first stage, with wounds area after debridement ranging from 8 cm×6 cm to 22 cm×14 cm, and continuous vacuum sealing drainage (VSD) was performed after the debridement operation. In the second stage, personalized surgery scheme was formulated according to the patient's age, systemic condition, vascular condition, and the position, size, and depth of wound. Six cases were reconstructed with superior/inferior gluteal artery perforator flaps, 4 cases were repaired with gluteus maximus myocutaneous flaps, 1 case was repaired with pedicled latissimus dorsi myocutaneous flap, and 1 case was reconstructed with free transplantation of latissimus dorsi myocutaneous flap. The area of flaps or myocutaneous flaps ranged from 10 cm×8 cm to 25 cm×18 cm. Donor sites of the flaps were sutured primarily in 9 patients and in the other 3 patients were repaired with intermediate split-thickness skin graft in back. The survival of flap or myocutaneous flap after operation, recurrence of tumor, and the appearance and texture of flap or myocutaneous flap, and wound healing were observed during follow-up. Flaps or myocutaneous flaps in 11 patients survived after operation, and superior gluteal artery perforator flap in 1 patient had partial distal necrosis, which was covered again with flap pushed to the distal after debridement and resection of the necrotic tissue. The wounds in 8 patients achieved primary healing, 1 patient repaired with superior gluteal artery perforator flap experienced subcutaneous infection, 1 patient repaired with superior gluteal artery perforator flap suffered distal venous congestion of the flap, and 1 patient repaired with gluteus maximus myocutaneous flap had hematoma under myocutaneous flap, and 1 patient repaired with retrograde latissimus dorsi myocutaneous flap had incision exudation and dehiscence, which were all healed after dressing change, etc. There was no recurrence of tumor after the operation. The wounds healed well during follow-up of 2-52 months after discharge, with no recurrence of infection, and the flaps were soft in texture, with satisfactory appearance and well healed donor sites. On the basis of thorough debridement and VSD in the first stage, superior/inferior gluteal artery perforator flap, gluteus maximus myocutaneous flap, or pedicled/free latissimus dorsi myocutaneous flap with abundant blood supply is applied to repair chronic sacrococcygeal radiation ulcer in the second stage. The staged operation is reliable, with minimal injury to the donor site of flap and satisfactory therapeutic effect.

摘要

探讨慢性骶尾部放射性溃疡分期修复策略的临床效果。采用回顾性队列研究方法。2010年1月至2020年6月,北京积水潭医院收治12例慢性骶尾部放射性溃疡患者,其中男性7例,女性5例,年龄38 - 74岁。第一期行彻底清创,清创后创面面积为8 cm×6 cm至22 cm×14 cm,清创术后行持续封闭负压引流(VSD)。第二期根据患者年龄、全身状况、血管条件以及创面的位置、大小和深度制定个性化手术方案。6例行臀上/下动脉穿支皮瓣修复,4例行臀大肌肌皮瓣修复,1例行带蒂背阔肌肌皮瓣修复,1例行游离背阔肌肌皮瓣移植修复。皮瓣或肌皮瓣面积为10 cm×8 cm至25 cm×18 cm。9例皮瓣供区直接缝合,另3例供区行背部中厚皮片移植修复。随访观察术后皮瓣或肌皮瓣存活情况、肿瘤复发情况、皮瓣或肌皮瓣外观及质地以及创面愈合情况。11例患者术后皮瓣或肌皮瓣存活,1例臀上动脉穿支皮瓣远端部分坏死,经清创切除坏死组织后将皮瓣向远端推进再次覆盖。8例患者创面一期愈合,1例臀上动脉穿支皮瓣修复患者发生皮下感染,1例臀上动脉穿支皮瓣修复患者出现皮瓣远端静脉淤血,1例臀大肌肌皮瓣修复患者肌皮瓣下出现血肿,1例逆行背阔肌肌皮瓣修复患者切口渗液、裂开,经换药等处理后均愈合。术后无肿瘤复发。出院后随访观察2 - 52个月,创面愈合良好,无感染复发,皮瓣质地柔软,外观满意,供区愈合良好。在第一期彻底清创及VSD的基础上,第二期采用血供丰富的臀上/下动脉穿支皮瓣、臀大肌肌皮瓣或带蒂/游离背阔肌肌皮瓣修复慢性骶尾部放射性溃疡。分期手术可靠,对皮瓣供区损伤小,治疗效果满意。

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