Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Adv Clin Chem. 2021;101:135-168. doi: 10.1016/bs.acc.2020.06.004. Epub 2020 Sep 24.
The increasing prevalence of obesity and the associated morbidity and mortality are important public health problems globally. There is an important relationship between an unhealthy lifestyle and increased serum inflammatory cytokines. Adipocytes secrete several pro-inflammatory cytokines involved in the recruitment and activation of macrophages resulting in chronic low-grade inflammation. Increased cytokines in obese individual are related to the progression of several disorders including cardiovascular disease, hypertension, and insulin resistance. In present review we have summarized the crucial roles of cytokines and their inflammatory functions in obesity-related immune disorders.
肥胖症的患病率不断上升，以及与之相关的发病率和死亡率，是全球范围内的重要公共卫生问题。不健康的生活方式与血清中炎症细胞因子的增加之间存在着重要的关系。脂肪细胞分泌几种参与招募和激活巨噬细胞的促炎细胞因子，导致慢性低度炎症。肥胖个体中细胞因子的增加与几种疾病的进展有关，包括心血管疾病、高血压和胰岛素抵抗。在本综述中，我们总结了细胞因子及其炎症功能在肥胖相关免疫紊乱中的关键作用。
