Wang Tingwen, Huang Jiaqing, Sun Xin, Zhao Hai, Bao Jun, Chu Xuehui, Bian Xiaojie
Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Department of Pharmacy, Nanjing Drum Tower Hospital, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Front Nutr. 2025 Aug 26;12:1618630. doi: 10.3389/fnut.2025.1618630. eCollection 2025.
To investigate the association between serum amino acid changes and alopecia in patients with obesity before and after bariatric surgery, and identify risk factors for postoperative alopecia.
This prospective cohort study (ChiCTR2300074104) included patients with obesity undergoing laparoscopic sleeve gastrectomy (LSG), categorized into non-mild alopecia (NM group, = 24) and moderate-severe alopecia (MS group, = 43) groups. Clinical data and serum amino acid concentrations were analyzed to: (1) compare preoperative and postoperative amino acid profiles; (2) evaluate amino acid differences between groups at various timepoints and correlate with alopecia severity; (3) perform logistic regression to identify alopecia risk factors.
Among 67 patients analyzed, LSG significantly decreased serum concentrations of arginine, alanine, threonine, glutamic acid, branched-chain amino acids (valine, isoleucine, leucine), and aromatic amino acids (tyrosine, phenylalanine, tryptophan) ( < 0.05), while serine and glycine increased ( < 0.05). At 3 months postoperatively, leucine levels were higher in the MS group compared to the NM group. Spearman's correlation analysis revealed threonine, -aminobutyric acid, and leucine levels were associated with alopecia severity ( < 0.05). Logistic regression identified serum leucine as an independent risk factor for postoperative alopecia (OR = 1.119, 95% CI 1.006-1.245, = 0.038).
LSG surgery alters the serum amino acid profile in patients with obesity, and serum leucine concentration at 3 months postoperatively is an influential factor in postoperative alopecia.
探讨减重手术前后肥胖患者血清氨基酸变化与脱发之间的关联，并确定术后脱发的危险因素。
这项前瞻性队列研究（ChiCTR2300074104）纳入了接受腹腔镜袖状胃切除术（LSG）的肥胖患者，分为非轻度脱发组（NM组，n = 24）和中度至重度脱发组（MS组，n = 43）。分析临床数据和血清氨基酸浓度，以：（1）比较术前和术后的氨基酸谱；（2）评估不同时间点各组之间的氨基酸差异，并与脱发严重程度相关联；（3）进行逻辑回归分析以确定脱发的危险因素。
在分析的67例患者中，LSG显著降低了精氨酸、丙氨酸、苏氨酸、谷氨酸、支链氨基酸（缬氨酸、异亮氨酸、亮氨酸）和芳香族氨基酸（酪氨酸、苯丙氨酸、色氨酸）的血清浓度（P < 0.05），而丝氨酸和甘氨酸升高（P < 0.05）。术后3个月，MS组的亮氨酸水平高于NM组。Spearman相关性分析显示，苏氨酸、γ-氨基丁酸和亮氨酸水平与脱发严重程度相关（P < 0.05）。逻辑回归分析确定血清亮氨酸是术后脱发的独立危险因素（OR = 1.119，95%CI 1.006 - 1.245，P = 0.038）。
LSG手术改变了肥胖患者的血清氨基酸谱，术后3个月的血清亮氨酸浓度是术后脱发的一个影响因素。
