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儿童和青少年癌症治疗患者的生育力考虑因素。

Fertility Considerations in Pediatric and Adolescent Patients Undergoing Cancer Therapy.

机构信息

Northwestern Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 East Chicago Avenue, Box 63, Chicago, IL 60611, USA.

University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.

出版信息

Surg Oncol Clin N Am. 2021 Apr;30(2):401-415. doi: 10.1016/j.soc.2020.11.009. Epub 2021 Feb 10.

Abstract

Survivors of pediatric cancer are at increased risk for infertility and premature hormonal failure. Surgeons caring for children with cancer have an important role to play in understanding this risk, as well as advocating for and performing appropriate fertility preservation procedures. Fertility preservation options in males and females vary by pubertal status and include nonexperimental (oocyte harvest, ovarian tissue cryopreservation, sperm cryopreservation) and experimental (testicular tissue cryopreservation) options. This review summarizes the basics of risk assessment and fertility preservation options and explores unique considerations in pediatric fertility preservation.

摘要

儿童癌症幸存者存在不孕和过早激素衰竭的风险增加。照顾癌症儿童的外科医生在了解这种风险方面以及倡导和进行适当的生育力保存程序方面发挥着重要作用。男性和女性的生育力保存选择因青春期状态而异,包括非实验性(卵母细胞采集、卵巢组织冷冻保存、精子冷冻保存)和实验性(睾丸组织冷冻保存)选择。这篇综述总结了风险评估和生育力保存选择的基础知识,并探讨了儿科生育力保存中的独特考虑因素。

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