Cardiovascular and Muscle Research Laboratory, Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Cardiovascular and Muscle Research Laboratory, Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Vitam Horm. 2021;115:449-475. doi: 10.1016/bs.vh.2020.12.018. Epub 2021 Feb 13.
Aging constitutes a major risk factor toward the development of cardiovascular diseases (CVDs). The aging heart undergoes several changes at the molecular, cellular and physiological levels, which diminishes its contractile function and weakens stress tolerance. Further, old age increases the exposure to risk factors such as hypertension, diabetes and hypercholesterolemia. Notably, research in the past decades have identified FoxO subfamily of the forkhead transcription factors as key players in regulating diverse cellular processes linked to cardiac aging and diseases. In the present chapter, we discuss the important role of FoxO in the development of various aging-associated cardiovascular complications such as cardiac hypertrophy, cardiac fibrosis, heart failure, vascular dysfunction, atherosclerosis, hypertension and myocardial ischemia. Besides, we will also discuss the role of FoxO in cardiometabolic alterations, autophagy and proteasomal degradation, which are implicated in aging-associated cardiac dysfunction.
衰老是导致心血管疾病（CVDs）的主要危险因素。衰老的心脏在分子、细胞和生理水平上经历了多种变化，这降低了它的收缩功能并减弱了对压力的耐受能力。此外，老年会增加高血压、糖尿病和高胆固醇血症等危险因素的暴露。值得注意的是，过去几十年的研究已经确定 FoxO 叉头转录因子亚家族是调节与心脏衰老和疾病相关的多种细胞过程的关键因素。在本章中，我们讨论了 FoxO 在各种与衰老相关的心血管并发症（如心脏肥大、心脏纤维化、心力衰竭、血管功能障碍、动脉粥样硬化、高血压和心肌缺血）的发展中的重要作用。此外，我们还将讨论 FoxO 在涉及与衰老相关的心脏功能障碍的心脏代谢改变、自噬和蛋白酶体降解中的作用。
