FoxO 家族与心脏功能和功能障碍。
The FoxO family in cardiac function and dysfunction.
机构信息
McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599, USA.
出版信息
Annu Rev Physiol. 2010;72:81-94. doi: 10.1146/annurev-physiol-021909-135931.
Abstract
The Forkhead family of transcription factors mediates many aspects of physiology, including stress response, metabolism, commitment to apoptosis, and development. The Forkhead box subfamily O (FoxO) proteins have garnered particular interest due to their involvement in the modulation of cardiovascular biology. In this review, we discuss the mechanisms of FoxO regulation and outcomes of FoxO signaling under normal and pathological cardiovascular contexts.
摘要
叉头框转录因子家族介导许多生理过程，包括应激反应、代谢、凋亡的启动和发育。叉头框亚家族 O（FoxO）蛋白因其参与心血管生物学的调节而备受关注。在这篇综述中，我们讨论了 FoxO 调节的机制以及在正常和病理心血管环境下 FoxO 信号的结果。
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