黄体生成素与衰老的大脑。
Luteinizing hormone and the aging brain.
机构信息
Department of Biomedical Science, Kent State University, Cunningham Hall, Kent, OH, United States.
Department of Biological Science, School of Arts and Sciences, Kent State University, Cunningham Hall, Kent, OH, United States.
出版信息
Vitam Horm. 2021;115:89-104. doi: 10.1016/bs.vh.2020.12.005.
Fluctuations in luteinizing hormone (LH) release contribute to the development and maintenance of the reproductive system and become dysregulated during aging. Of note, increasing evidence supports extra-gonadal roles for LH within the CNS, particularly as it relates to cognition and plasticity in aging and age-related degenerative diseases such as Alzheimer's disease (AD). However, despite increasing evidence that supports a link between this hormone and CNS function, the mechanisms underlying LH action within the brain and how they influence cognition and plasticity during the lifespan is poorly understood and, in fact, often in conflict. This chapter aims to provide an up-to-date review of the literature addressing the role of LH signaling in the context of CNS aging and disease and put forward a unifying hypothesis that may explain currently conflicting theories regarding the role of LHCGR signaling in CNS function and dysfunction in aging and disease.
黄体生成素 (LH) 释放的波动有助于生殖系统的发育和维持，并在衰老过程中失调。值得注意的是，越来越多的证据支持 LH 在中枢神经系统中的性腺外作用，特别是与衰老和与年龄相关的退行性疾病（如阿尔茨海默病）相关的认知和可塑性有关。然而，尽管有越来越多的证据支持这种激素与中枢神经系统功能之间存在联系，但 LH 在大脑中的作用机制以及它们如何在整个生命周期中影响认知和可塑性仍知之甚少，事实上，这种机制经常存在冲突。本章旨在对现有文献进行综述，探讨 LH 信号在中枢神经系统衰老和疾病中的作用，并提出一个统一的假说，该假说可能解释目前关于 LHCGR 信号在衰老和疾病中的中枢神经系统功能和功能障碍中的作用的相互矛盾的理论。
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