Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, UK.
Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK.
Nat Commun. 2021 Mar 11;12(1):1592. doi: 10.1038/s41467-021-21669-4.
Parkinson's disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum, a non-invasively available biofluid. We used liquid chromatography-mass spectrometry (LC-MS) to analyse 274 samples from participants (80 drug naïve PD, 138 medicated PD and 56 well matched control subjects) and detected metabolites that could predict PD phenotype. Pathway enrichment analysis shows alterations in lipid metabolism related to the carnitine shuttle, sphingolipid metabolism, arachidonic acid metabolism and fatty acid biosynthesis. This study shows sebum can be used to identify potential biomarkers for PD.
帕金森病（PD）是一种进行性神经退行性疾病，其特征是包括黑质多巴胺能神经元在内的特定神经元群体的退化。在这里，我们使用代谢组学分析方法来鉴定皮脂中观察到的帕金森病的脂质变化，皮脂是一种非侵入性的生物流体。我们使用液相色谱-质谱（LC-MS）分析了 274 名参与者（80 名未用药的 PD 患者、138 名用药的 PD 患者和 56 名匹配良好的对照组）的样本，并检测到可预测 PD 表型的代谢物。途径富集分析显示，与肉碱穿梭、鞘脂代谢、花生四烯酸代谢和脂肪酸生物合成相关的脂质代谢发生改变。这项研究表明皮脂可用于鉴定 PD 的潜在生物标志物。
