Rao Shan, Oyang Linda, Liang Jiaxin, Yi Pin, Han Yaqian, Luo Xia, Xia Longzheng, Lin Jinguan, Tan Shiming, Hu Jiaqi, Wang Hui, Tang Lu, Pan Qing, Tang Yanyan, Zhou Yujuan, Liao Qianjin
Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, People's Republic of China.
University of South China, Hengyang, 421001, Hunan, People's Republic of China.
Onco Targets Ther. 2021 Mar 5;14:1727-1735. doi: 10.2147/OTT.S297332. eCollection 2021.
Various stimuli induce an unfolded protein response to endoplasmic reticulum stress, accompanied by the expression of endoplasmic reticulum molecular chaperones. Hypoxia-upregulated 1 gene (HYOU1) is a chaperone protein located in the endoplasmic reticulum. HYOU1 expression was upregulated in many diseases, including various cancers and endoplasmic reticulum stress-related diseases. HYOU1 does not only play an important protective role in the occurrence and development of tumors, but also is a potential therapeutic target for cancer. HYOU1 may also be used as an immune stimulation adjuvant because of its anti-tumor immune response, and a molecular target for therapy of many endoplasmic reticulum-related diseases. In this article, we summarize the updates in HYOU1 and discuss the potential therapeutic effects of HYOU1.
多种刺激可诱导内质网应激的未折叠蛋白反应，并伴有内质网分子伴侣的表达。缺氧上调基因1（HYOU1）是一种位于内质网的伴侣蛋白。HYOU1在包括各种癌症和内质网应激相关疾病在内的许多疾病中表达上调。HYOU1不仅在肿瘤的发生和发展中发挥重要的保护作用，还是癌症的潜在治疗靶点。由于其抗肿瘤免疫反应，HYOU1还可作为免疫刺激佐剂，以及许多内质网相关疾病治疗的分子靶点。在本文中，我们总结了HYOU1的最新研究进展，并讨论了HYOU1的潜在治疗作用。
