Karimian Mohammad, Azami Milad
Department of General Surgery, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Pol J Radiol. 2021 Jan 14;86:e31-e49. doi: 10.5114/pjr.2021.103379. eCollection 2021.
Numerous cases of pneumonia caused by coronavirus disease 2019 (COVID-19) were reported in Wuhan, China. Chest computed tomography (CT) scan is highly important in the diagnosis and follow-up of lung disease treatment. The present meta-analysis was performed to evaluate chest CT scan findings in COVID-19 patients.
All research steps were taken according to the Meta-Analysis of Observational Studies In Epidemiology (MOOSE) protocol and the final report was based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We registered this review at the International Prospective Register of Systematic Reviews (PROSPERO, CRD42019127858).
Forty eligible studies including 4598 patients with COVID-19 were used for meta-analysis. The rate of positive chest CT scan in patients with COVID-19 was 94.5% (95% CI: 91.7-96.3). Bilateral lung involvement, pure ground-glass opacity (GGO), mixed (GGO pulse consolidation or reticular), consolidation, reticular, and presence of nodule findings in chest CT scan of COVID-19 pneumonia patients were respectively estimated to be 79.1% (95% CI: 70.8-85.5), 64.9% (95% CI: 54.1-74.4), 49.2% (95% CI: 35.7-62.8), 30.3% (95% CI: 19.6-43.6), 17.0% (95% CI: 3.9-50.9) and 16.6% (95% CI: 13.6-20.2). The distribution of lung lesions in patients with COVID-19 pneumonia was peripheral (70.0% [95% CI: 57.8-79.9]), central (3.9% [95% CI: 1.4-10.6]), and peripheral and central (31.1% [95% CI: 19.5-45.8]). The pulmonary lobes most commonly involved were the right lower lobe (86.5% [95% CI:57.7-96.8]) and left lower lobe (81.0% [95% CI: 50.5-94.7]).
The most important outcomes in chest CT scan of patients with COVID-19 pneumonia were bilateral lung involvement, GGO or mixed (GGO pulse consolidation or reticular) patterns, thickened interlobular septa, vascular enlargement, air bronchogram sign, peripheral distribution, and left and right lower lobes involvement. Our study showed that chest CT scan has high sensitivity in the diagnosis of COVID-19, and may therefore serve as a standard method for diagnosis of COVID-19.
中国武汉报告了大量由2019冠状病毒病（COVID-19）引起的肺炎病例。胸部计算机断层扫描（CT）在肺部疾病治疗的诊断和随访中非常重要。本荟萃分析旨在评估COVID-19患者的胸部CT扫描结果。
所有研究步骤均按照流行病学观察性研究的荟萃分析（MOOSE）方案进行，最终报告基于系统评价和荟萃分析的首选报告项目（PRISMA）指南。我们在国际前瞻性系统评价注册库（PROSPERO，CRD42019127858）中注册了本综述。
40项符合条件的研究，包括4598例COVID-19患者，用于荟萃分析。COVID-19患者胸部CT扫描阳性率为94.5%（95%CI：91.7-96.3）。COVID-19肺炎患者胸部CT扫描中双侧肺受累、单纯磨玻璃影（GGO）、混合性（GGO伴实变或网状）、实变、网状及结节表现的发生率分别估计为79.1%（95%CI：70.8-85.5）、64.9%（95%CI：54.1-74.4）、49.2%（95%CI：35.7-62.8）、30.3%（95%CI：19.6-43.6）、17.0%（95%CI：3.9-50.9）和16.6%（95%CI：13.6-20.2）。COVID-19肺炎患者肺部病变的分布为外周型（70.0%[95%CI：
