Department of General Internal Medicine, Ningbo City First Hospital, Haishu District, Ningbo, Zhejiang Province 315000.
Department of Infectious Disease, Affiliated Hospital of Shaoxing University/Shaoxing Municipal Hospital, Yuecheng District, Shaoxing City, Zhejiang Province 312000.
QJM. 2020 Jul 1;113(7):474-481. doi: 10.1093/qjmed/hcaa089.
Recent studies have focused on initial clinical and epidemiological characteristics of the coronavirus disease 2019 (COVID-19), which is the mainly revealing situation in Wuhan, Hubei.
This study aims to reveal more data on the epidemiological and clinical characteristics of COVID-19 patients outside of Wuhan, Zhejiang, China.
This study was a retrospective case series.
Eighty-eight cases of laboratory-confirmed and three cases of clinically confirmed COVID-19 were admitted to five hospitals in Zhejiang province, China. Data were collected from 20 January 2020 to 11 February 2020.
Of all 91 patients, 88 (96.70%) were laboratory-confirmed COVID-19 with throat swab samples that tested positive for SARS-Cov-2, three (3.30%) cases were clinically diagnosed. The median age of the patients was 50 (36.5-57) years, and female accounted for 59.34%. In this sample, 40 (43.96%) patients had contracted the disease from local cases, 31 (34.07%) patients had been to Wuhan/Hubei, eight (8.79%) patients had contacted with people from Wuhan, and 11 (12.09%) patients were diagnosed after having flown together in the same flight with no passenger that could later be identified as the source of infection. In particular within the city of Ningbo, 60.52% cases can be traced back to an event held in a temple. The most common symptoms were fever (71.43%), cough (60.44%) and fatigue (43.96%). The median of incubation period was 6 (interquartile range 3-8) days and the median time from the first visit to a doctor to the confirmed diagnosis was 1 (1-2) days. According to the chest computed tomography scans, 67.03% cases had bilateral pneumonia.
Social activity cluster, family cluster and flying alongside with persons already infected with COVID-19 were how people got infected with COVID-19 in Zhejiang.
近期研究主要聚焦于 2019 年冠状病毒病（COVID-19）的首发临床和流行病学特征，这些研究揭示了湖北武汉的主要情况。
本研究旨在揭示中国浙江武汉以外地区 COVID-19 患者的更多流行病学和临床特征。
本研究为回顾性病例系列研究。
2020 年 1 月 20 日至 2 月 11 日期间，收集了中国浙江省 5 家医院收治的 88 例经实验室确诊和 3 例临床确诊的 COVID-19 患者的数据。
所有 91 例患者中，88 例（96.70%）为经咽拭子样本 SARS-CoV-2 检测阳性的实验室确诊 COVID-19 患者，3 例（3.30%）为临床确诊。患者中位年龄为 50（36.5-57）岁，女性占 59.34%。在该样本中，40（43.96%）例患者因本地病例感染，31（34.07%）例患者去过武汉/湖北，8（8.79%）例患者接触过武汉人，11（12.09%）例患者与无法识别的同航班感染源乘客一同乘机后确诊。特别是在宁波市，60.52%的病例可追溯到寺庙活动。最常见的症状是发热（71.43%）、咳嗽（60.44%）和乏力（43.96%）。潜伏期中位数为 6（四分位距 3-8）天，从首次就诊到确诊的中位时间为 1（1-2）天。根据胸部计算机断层扫描结果，67.03%的病例有双侧肺炎。
在浙江，COVID-19 人际传播途径包括社交活动聚集、家庭聚集和与 COVID-19 感染者同乘航班。
