Sharifpour Ali, Safanavaei Sepideh, Tabaripour Rabeeh, Taghizadeh Fatemeh, Nakhaei Maryam, Abadi Atikeh, Fakhar Mahdi, Banimostafavi Elham Sadat, Nazar Eisa, Aliyali Masoud, Abedi Siavash, Mehravaran Hossein, Zakariaei Zakaria, Azadeh Hossein
Toxoplasmosis Research Center, Communicable Diseases Institute, Iranian National Registry Center for Lophomoniasis (INRCL), Mazandaran University of Medical Sciences, Sari, Iran.
Pulmonary and Critical Care Division, Imam Khomeini Hospital, Iranian National Registry Center for Lophomoniasis (INRCL), Mazandaran University of Medical Sciences, Sari, Iran.
Ann Med Surg (Lond). 2021 Jul;67:102519. doi: 10.1016/j.amsu.2021.102519. Epub 2021 Jun 24.
The clinical symptoms, blood laboratory data, O2 saturation and high-resolution computed tomography (HRCT) findings are critical factors in diagnosis of COVID-19 infection.
In this study, 105 hospitalized patients suspected of having COVID-19 were evaluated. Finally, the laboratory and HRCT and related factors data of 83 confirmed cases by HRCT and RT-PCR were analyzed. To compare the median of quantitative variables in the two groups, the Mann-Whitney test was used. Also, to determine the factors associated with the positiveness of the HRCT result, a univariate logistic model was fitted. Moreover, receiver operating characteristic (ROC) curves were constructed to test the ability of the final model to predict the positiveness of HRCT result.
61.40% of the patients had a comorbidity disease. 89.20% had fever, 92.00% cough, 91.40% dyspnea. Abnormal CRP was seen in 77.80% of the patients, followed by 66.70% lymphopenia, and 60.30% neutrophilia. Also, ALP (abnormal vs. normal) and score of HRCT assessment variables had a significant effect on the positiveness of HRCT findings. 87.95% had abnormal HRCT with 41% bilateral multi lobar patchy ground glass opacity (GGO). Moreover, there was a statistically significant association between the level of O2 saturation and HRCT results.
Our findings showed that male patients with middle age and comorbidity disease were more susceptible to the COVID-19 infection. Additionally, clinical features, blood laboratory findings, O2 saturation and HRCT findings are critical factors in the prognosis of COVID-19 infection.
临床症状、血液实验室数据、血氧饱和度及高分辨率计算机断层扫描（HRCT）结果是诊断新型冠状病毒肺炎（COVID-19）感染的关键因素。
本研究对105例疑似COVID-19的住院患者进行了评估。最终，对83例经HRCT和逆转录聚合酶链反应（RT-PCR）确诊病例的实验室检查、HRCT及相关因素数据进行了分析。为比较两组定量变量的中位数，采用了曼-惠特尼检验。此外，为确定与HRCT结果阳性相关的因素，拟合了单变量逻辑模型。而且，构建了受试者工作特征（ROC）曲线以检验最终模型预测HRCT结果阳性的能力。
61.40%的患者患有合并症。89.20%的患者发热，92.00%咳嗽，91.40%呼吸困难。77.80%的患者C反应蛋白（CRP）异常，其次是66.70%淋巴细胞减少，60.30%中性粒细胞增多。此外，碱性磷酸酶（ALP，异常与正常）及HRCT评估变量评分对HRCT结果的阳性有显著影响。87.95%的患者HRCT异常，其中41%为双侧多叶斑片状磨玻璃影（GGO）。而且，血氧饱和度水平与HRCT结果之间存在统计学显著关联。
我们的研究结果表明，中年男性及患有合并症的患者更容易感染COVID-19。此外，临床特征、血液实验室检查结果、血氧饱和度及HRCT结果是COVID-19感染预后的关键因素。
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