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心力衰竭:心脏重症专家的角色与观点

Heart failure: role and point of view of cardiac intensivist.

作者信息

Benedetto Maria, Nardozi Ludovica, Baca Georgiana Luisa, Loforte Antonio, Baiocchi Massimo

机构信息

Cardiothoracic and Vascular Anesthesia and Intensive Care Unit, Sant' Orsola Malpighi University Hospital, Bologna, Italy.

Barts Heart Center, St. Bartholomew's Hospital, London, UK.

出版信息

Cardiovasc Diagn Ther. 2021 Feb;11(1):301-308. doi: 10.21037/cdt-20-339.

Abstract

Heart failure is an acute or chronic syndrome where the heart is unable to provide adequate amount of oxygen to body tissues. The treatment of heart failure aims to give an immediate answer in terms of regression of volume overload and restoration of hemodynamic stability and then to ensure management of clinical exacerbation, reduction in hospital stay, and increasing of survival. The pharmacological treatment of heart failure includes drugs with different strength of evidence. When the patient is no more responsive to medical therapy a non-pharmacological approach may be required. The first step is cardiac resynchronization therapy and implantable cardiac defibrillator. Then hospitalization and inotropic support may be needed. When cardiac disease reaches the end stage, the severe decrease in multi organ perfusion requires a quick therapeutic response. This is a time dependent scenario, when mechanical circulatory support (MCS) plays a crucial role. MCS may be used as temporary hemodynamic support on situations where myocardial recovery is likely, such as after revascularization and in cases of fulminant acute myocarditis. Conversion to ventricular assist devices or transplantation should be considered if longer duration of MCS is required. Advances in the treatment of cardiogenic shock patients in terms of pharmacological therapies, short term and long term MCS could provide opportunities to improve survival, but they also increase the complexity of clinical care. For this reason a multidisciplinary shock team approach is paramount for early symptom detection, to guide initial haemodynamic therapy and for the right choice of MCS device at the right time.

摘要

心力衰竭是一种急性或慢性综合征,其中心脏无法为身体组织提供足够的氧气。心力衰竭的治疗旨在立即解决容量超负荷的消退和血流动力学稳定性的恢复问题,然后确保控制临床病情加重、缩短住院时间并提高生存率。心力衰竭的药物治疗包括证据强度不同的药物。当患者对药物治疗不再有反应时,可能需要采取非药物治疗方法。第一步是心脏再同步治疗和植入式心脏除颤器。然后可能需要住院治疗和使用正性肌力药物支持。当心脏疾病发展到终末期时,多器官灌注的严重下降需要迅速的治疗反应。这是一个时间依赖性的情况,此时机械循环支持(MCS)起着至关重要的作用。MCS可在心肌恢复可能性较大的情况下用作临时血流动力学支持,例如在血管重建后和暴发性急性心肌炎的情况下。如果需要更长时间的MCS,则应考虑转换为心室辅助装置或进行移植。在药物治疗、短期和长期MCS方面,心源性休克患者治疗的进展可以提供提高生存率的机会,但也增加了临床护理的复杂性。因此,多学科休克治疗团队的方法对于早期症状检测、指导初始血流动力学治疗以及在正确的时间正确选择MCS装置至关重要。

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本文引用的文献

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Mechanical Circulatory Support in Patients with Cardiogenic Shock.心源性休克患者的机械循环支持
Curr Treat Options Cardiovasc Med. 2020 Jan 30;22(2):4. doi: 10.1007/s11936-020-0804-6.
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One-Year Outcomes after PCI Strategies in Cardiogenic Shock.心源休克患者经皮冠状动脉介入治疗策略的一年预后
N Engl J Med. 2018 Nov 1;379(18):1699-1710. doi: 10.1056/NEJMoa1808788. Epub 2018 Aug 25.

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