Ghafouri-Fard Soudeh, Gholipour Mahdi, Taheri Mohammad
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Cardiovasc Med. 2021 Feb 23;8:632393. doi: 10.3389/fcvm.2021.632393. eCollection 2021.
Coronary artery disease (CAD) is a common disorder caused by atherosclerotic processes in the coronary arteries. This condition results from abnormal interactions between numerous cell types in the artery walls. The main participating factors in this process are accumulation of lipid deposits, endothelial cell dysfunction, macrophage induction, and changes in smooth muscle cells. Several lines of evidence underscore participation of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in the pathogenesis of CAD. Several lncRNAs such as H19, ANRIL, MIAT, lnc-DC, IFNG-AS1, and LEF1-AS1 have been shown to be up-regulated in the biological materials obtained from CAD patients. On the other hand, Gas5, Chast, HULC, DICER1-AS1, and MEG3 have been down-regulated in CAD patients. Meanwhile, a number of circRNAs have been demonstrated to influence function of endothelial cells or vascular smooth muscle cells, thus contributing to the pathogenesis of CAD. In the current review, we summarize the function of lncRNAs and circRNAs in the development and progression of CAD.
冠状动脉疾病（CAD）是一种由冠状动脉粥样硬化过程引起的常见病症。这种情况源于动脉壁中多种细胞类型之间的异常相互作用。该过程中的主要参与因素包括脂质沉积的积累、内皮细胞功能障碍、巨噬细胞诱导以及平滑肌细胞的变化。多条证据强调了长链非编码RNA（lncRNA）和环状RNA（circRNA）在CAD发病机制中的参与。一些lncRNA，如H19、ANRIL、MIAT、lnc-DC、IFNG-AS1和LEF1-AS1，已被证明在从CAD患者获得的生物材料中上调。另一方面，Gas5、Chast、HULC、DICER1-AS1和MEG3在CAD患者中下调。同时，一些circRNA已被证明会影响内皮细胞或血管平滑肌细胞的功能，从而导致CAD的发病机制。在本综述中，我们总结了lncRNA和circRNA在CAD发生发展中的作用。
