长链非编码RNA在冠状动脉疾病发病机制中的作用
Role of LncRNAs in the Pathogenesis of Coronary Artery Disease.
作者信息
Wu Xinyu, Li Jingru, Sun Guihu, Yang Jun, Peng Yunzhu, Bai Xiangfeng, Wang Luqiao
机构信息
Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, 650032 Kunming, Yunnan, China.
Department of Cardiac Surgery, The First Affiliated Hospital of Kunming Medical University, 650032 Kunming, Yunnan, China.
出版信息
Rev Cardiovasc Med. 2023 Mar 23;24(4):96. doi: 10.31083/j.rcm2404096. eCollection 2023 Apr.
Coronary artery disease (CAD), caused by coronary artery occlusion, is a common cardiovascular disease worldwide. Long non-coding RNAs (lncRNAs) are implicated in the regulation of endothelial cell injury, angiogenesis, plaque formation, and other pathological mechanisms in CAD by acting on different cell types. Some lncRNAs are significantly upregulated in CAD patients; however, other lncRNAs are significantly downregulated. Differential expression of lncRNAs in CAD patients enables them to be exploited as potential biomarkers to evaluate disease progression and diagnosis/prognosis in CAD patients. In this study, we reviewed the role of lncRNAs in the development of different clinical subtypes of CAD.
冠状动脉疾病（CAD）由冠状动脉闭塞引起，是全球常见的心血管疾病。长链非编码RNA（lncRNAs）通过作用于不同细胞类型，参与CAD中内皮细胞损伤、血管生成、斑块形成及其他病理机制的调控。一些lncRNAs在CAD患者中显著上调；然而，其他lncRNAs则显著下调。CAD患者中lncRNAs的差异表达使其有望作为潜在生物标志物，用于评估CAD患者的疾病进展及诊断/预后。在本研究中，我们综述了lncRNAs在CAD不同临床亚型发生发展中的作用。
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