Chen Chongxiang, Hu Qiaozhen, Wang Jiaojiao, Wen Tianmeng, Zhu Chaoyang, Tan Weiyan, Chen Xuelin, Zhao Qingyu, Wang Wei, Cao Huijiao, Li Huan
Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Guangzhou Institute of Respiratory Diseases, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou, China.
Ann Transl Med. 2021 Feb;9(3):263. doi: 10.21037/atm-20-3063.
The objective of this study was to determine the causal relationship between habitual alcohol consumption with meals and lung cancer.
Public genetic summary data from two large consortia [the Neale Lab and the International Lung Cancer Consortium (ILCCO)] were used for analysis. As the instrumental variables of habitual alcohol consumption with meals, data on genetic variants were retrieved from Neale Lab. Additionally, genetic data from other consortia [Global Lipid Genetics Consortium (GLGC), Tobacco, Alcohol and Genetics (TAG), Genetic Investigation of Anthropocentric Traits (GIANT)] were utilized to determine whether alcohol could causally alter some general risk factors for lung cancer. The primary outcome was the risk of lung cancer (11,348 cases and 15,861 controls in the ILCCO). The R package TwoSampleMR was used for analysis.
Based on the inverse variance weighted method, the results of the two-sample Mendelian randomization (MR) analyses indicated that commonly consuming alcohol with meals was a protective factor, reducing lung cancer risk [odds ratio (OR) 0.175, 95% confidence interval (CI): 0.045-0.682, P=0.012]. The heterogeneity analysis revealed that the causal relationship analyses of different types of lung cancer all had low heterogeneity (P>0.05). The horizontal pleiotropic study showed that major bias was unlikely. The MR assumptions did not seem to be violated. The causal relationship analyses between habitual alcohol consumption with meals and some risk factors for cancers showed that this alcohol consumption habit was a beneficial factor for reducing body mass index (BMI) and the number of cigarettes smoked per day.
Habitual appropriate alcohol consumption with meals is a protective factor for the development of lung cancer.
本研究的目的是确定进餐时习惯性饮酒与肺癌之间的因果关系。
使用来自两个大型联盟（尼尔实验室和国际肺癌联盟（ILCCO））的公共基因汇总数据进行分析。作为进餐时习惯性饮酒的工具变量，从尼尔实验室检索基因变异数据。此外，利用来自其他联盟（全球脂质遗传学联盟（GLGC）、烟草、酒精与遗传学（TAG）、人类中心性状基因研究（GIANT））的基因数据来确定酒精是否会因果性地改变一些肺癌的一般风险因素。主要结局是肺癌风险（ILCCO中有11348例病例和15861例对照）。使用R包TwoSampleMR进行分析。
基于逆方差加权法，两样本孟德尔随机化（MR）分析结果表明，进餐时经常饮酒是一个保护因素，可降低肺癌风险[比值比（OR）0.175，95%置信区间（CI）：0.045 - 0.682，P = 0.012]。异质性分析显示，不同类型肺癌的因果关系分析均具有低异质性（P > 0.05）。水平多效性研究表明不太可能存在主要偏倚。MR假设似乎未被违反。进餐时习惯性饮酒与一些癌症风险因素之间的因果关系分析表明，这种饮酒习惯是降低体重指数（BMI）和每日吸烟量的有益因素。
进餐时习惯性适量饮酒是肺癌发生的一个保护因素。
