Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China.
West China School of Medicine, Sichuan University, Chengdu, China.
Cancer Med. 2023 Sep;12(17):18418-18424. doi: 10.1002/cam4.6406. Epub 2023 Aug 7.
The association between adult body mass index (BMI) and lung cancer (LC) susceptibility have been reported, but the causal relationship with childhood BMI remains largely unclear. To evaluate the causal effect of childhood BMI on LC susceptibility, a two-sample Mendelian randomization (MR) study was performed.
The two-sample MR analysis utilized 25 single nucleotide polymorphisms (SNPs) as instrumental variables for childhood BMI. Genetic summary data from the International Lung Cancer Consortium and FinnGen databases were analyzed to estimate the causal effect of these SNPs on LC susceptibility. The IVW method was employed as the primary analysis, supplemented by the Weighted Median, MR-Egger, and MR pleiotropy residual sum and outlier test.
Our findings indicated that there was no causal association between childhood BMI and the susceptibility of LC (odds ratio [OR]: 1.03, 95% confidence interval [CI]: 0.90-1.17, p = 0.705), lung adenocarcinoma (OR: 0.99, 95% CI: 0.86-1.13, p = 0.832), lung squamous cell carcinoma (OR: 0.97, 95% CI: 0.84-1.13, p = 0.726), and small cell LC (OR: 1.09, 95% CI: 0.82-1.45, p = 0.554) based on the IVW as well as other methods employed. Furthermore, these findings indicated no causal effect of childhood BMI on the LC susceptibility in both ever smokers and never smokers.
This study did not conclude a causal effect between childhood BMI and LC susceptibility. However, given the complex nature of cancer development, further studies are needed to verify these findings.
已有研究报道成人体重指数（BMI）与肺癌（LC）易感性之间存在关联，但儿童 BMI 与 LC 易感性之间的因果关系仍不清楚。为了评估儿童 BMI 对 LC 易感性的因果效应，进行了一项两样本 Mendelian 随机化（MR）研究。
两样本 MR 分析使用 25 个单核苷酸多态性（SNP）作为儿童 BMI 的工具变量。对来自国际肺癌联盟和芬兰基因数据库的遗传汇总数据进行分析，以估计这些 SNP 对 LC 易感性的因果效应。采用 IVW 法作为主要分析方法，同时补充加权中位数、MR-Egger 和 MR 偏倚残差和异常值检验。
我们的研究结果表明，儿童 BMI 与 LC（比值比 [OR]：1.03，95%置信区间 [CI]：0.90-1.17，p=0.705）、肺腺癌（OR：0.99，95%CI：0.86-1.13，p=0.832）、肺鳞癌（OR：0.97，95%CI：0.84-1.13，p=0.726）和小细胞 LC（OR：1.09，95%CI：0.82-1.45，p=0.554）的易感性之间没有因果关系，这一结论基于 IVW 以及其他使用的方法。此外，这些发现表明儿童 BMI 对无论是否吸烟的个体的 LC 易感性均无因果效应。
本研究未得出儿童 BMI 与 LC 易感性之间存在因果关系的结论。然而，鉴于癌症发展的复杂性，需要进一步的研究来验证这些发现。
