Analysis of the Expression of Genes and Its Prognostic Significance in Human Lung Carcinoma: A Review of the Literature Databases.

BACKGROUND

Lung cancer (LC) has become the top cause responsible for cancer-related deaths. genes exert an important role in the life process. Dysregulation in the process of cell division may lead to malignancy.

METHODS

Transcriptional data on gene family and patient survival data were examined for lung cancer (LC) patients from the GEPIA, Oncomine, cBioPortal, and Kaplan-Meier Plotter databases.

RESULTS

expression levels were higher in lung adenocarcinoma tissues, and the expression levels were increased in squamous cell LC tissues compared with those in noncarcinoma lung tissues. The expression levels of showed correlation with tumor classification. The Kaplan-Meier Plotter database was employed to carry out survival analysis, indicating that increased expression levels were increased in squamous cell LC tissues compared with those in noncarcinoma lung tissues. The expression levels of < 0.05). Only LC patients with increased expression were significantly related to lower post-progression survival (PPS) ( < 0.05). Only LC patients with increased gene family and patient survival data were examined for lung cancer (LC) patients from the GEPIA, Oncomine, cBioPortal, and Kaplan-Meier Plotter databases. , , and ); CORUM: 127: NDC80 kinetochore complex; M129: the PID PLK1 pathway; and GO: 0007080: mitotic metaphase plate congression, all of which were remarkably modulated since the alterations affected gene family and patient survival data were examined for lung cancer (LC) patients from the GEPIA, Oncomine, cBioPortal, and Kaplan-Meier Plotter databases.

CONCLUSIONS

Upregulated genes' expression levels in LC tissues probably play a crucial part in LC oncogenesis. The upregulated genes' expression levels are used as the potential prognostic markers to improve patient survival and the LC prognostic accuracy. genes probably exert their functions in tumorigenesis through the PLK1 pathway. gene family and patient survival data were examined for lung cancer (LC) patients from the GEPIA, Oncomine, cBioPortal, and Kaplan-Meier Plotter databases. gene family and patient survival data were examined for lung cancer (LC) patients from the GEPIA, Oncomine, cBioPortal, and Kaplan-Meier Plotter databases. gene family and patient survival data were examined for lung cancer (LC) patients from the GEPIA, Oncomine, cBioPortal, and Kaplan-Meier Plotter databases.