Moosazadeh Mahmood, Nabinezhad-Male Fatemeh, Afshari Mahdi, Nasehi Mohammad Mehdi, Shabani Mohammad, Kheradmand Motahareh, Aghaei Iraj
Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Mazandaran University of Medical Sciences, Sari, Iran.
AIMS Neurosci. 2021 Feb 5;8(2):239-253. doi: 10.3934/Neuroscience.2021013. eCollection 2021.
Association between the serum vitamin D level and disability of patients with multiple sclerosis (MS) has been investigated during several researches. However, these studies reported different results. The current study aims to estimate the correlation between the concentrations of 25 (OH) vitamin D and the level of disability among MS patients. Using Mesh and non-Mesh terms related to MS, disability level and vitamin D, different data banks were searched. Required information was extracted from the selected eligible primary articles. Stata version 11 software was applied for combining the primary correlation coefficients using random effect model. The effect of MS type and patients' age was assessed using meta-regression models. Sensitivity analysis was performed to investigate the role of each primary study in the pooled estimate. Egger test was applied to find any publication bias. Of 14 eligible studies, the total correlation coefficient (95% confidence interval) between 25 (OH) vitamin D level and disability in both sexes as well as among female was estimated as of -0.29 (-0.40, -0.17) and -0.35 (-0.46, -0.24) respectively. Two articles carried out among male did not report significant results. Our meta-analysis showed a significant negative correlation between 25 (OH) vitamin D level and disability of MS patients so that the disability reduces with increasing the 25 (OH) vitamin D level.
在多项研究中，已对血清维生素D水平与多发性硬化症（MS）患者残疾情况之间的关联进行了调查。然而，这些研究报告的结果各不相同。本研究旨在评估25（OH）维生素D浓度与MS患者残疾程度之间的相关性。使用与MS、残疾程度和维生素D相关的主题词和非主题词，检索了不同的数据库。从选定的符合条件的原始文章中提取所需信息。应用Stata 11版软件，使用随机效应模型合并主要相关系数。使用元回归模型评估MS类型和患者年龄的影响。进行敏感性分析以研究每项主要研究在汇总估计中的作用。应用Egger检验以发现是否存在发表偏倚。在14项符合条件的研究中，25（OH）维生素D水平与男女以及女性残疾之间的总相关系数（95%置信区间）分别估计为-0.29（-0.40，-0.17）和-0.35（-0.46，-0.24）。在男性中进行的两项研究未报告显著结果。我们的荟萃分析表明，25（OH）维生素D水平与MS患者的残疾之间存在显著负相关，即随着25（OH）维生素D水平的升高，残疾程度降低。
