Faculty of Medicine, University of Ottawa, Roger Guindon Hall, 451 Symth Road #2044, Ottawa, ON, K1H 8M5, Canada.
Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street, Toronto, ON, Canada.
Can J Anaesth. 2021 Jun;68(6):880-893. doi: 10.1007/s12630-021-01959-7. Epub 2021 Mar 11.
The objective of this study was to provide a synthesis of the interventions designed to reduce medication errors in anesthetized patients.
We electronically searched major databases using index and free-text keywords related to anesthesia and medication errors. We included cohort studies exploring interventions to reduce anesthetic medication errors in both adult and pediatric patients. The risk of bias for each study was assessed using the Newcastle-Ottawa Scale.
One thousand five-hundred and fifty-eight titles or abstracts were screened, and 56 full-text studies were assessed for eligibility; eight studies were included in the final analysis. Case reports and retrospective studies were excluded. The quality of most studies (n = 6) was graded as "low". There were three categories of interventions: I) multimodal interventions (6 studies, n = 900,170 medication administrations) showed a reduction in rates of errors of 21-35% per administration and 37-41% per anesthetic; II) improved labels (1 study, n = 55,426 medication administrations) resulted in a 37% reduction in rates of errors per anesthetic; and III) the effect of education was assessed in one study and showed no effect.
Multimodal interventions and improved labelling reduce medication errors in anesthetized patients.
本研究旨在综合干预措施，以减少麻醉患者的用药错误。
我们使用与麻醉和用药错误相关的索引词和自由词，对主要数据库进行电子检索。我们纳入了探索减少成人和儿科患者麻醉用药错误的干预措施的队列研究。使用纽卡斯尔-渥太华量表评估每个研究的偏倚风险。
筛选了 1558 个标题或摘要，评估了 56 篇全文研究的纳入资格；最终有 8 项研究纳入了分析。排除了病例报告和回顾性研究。大多数研究（n=6）的质量评为“低”。干预措施有三类：I）多模式干预（6 项研究，n=900170 次用药）使每次用药和每次麻醉的错误率降低 21-35%和 37-41%；II）改进标签（1 项研究，n=55426 次用药）使错误率降低 37%；III）一项研究评估了教育的效果，没有显示效果。
多模式干预和改进标签可减少麻醉患者的用药错误。
